TCONS_00002351-protein (polypeptide) - C. hemisphaerica

Overview


Name	TCONS_00002351-protein
Unique Name	TCONS_00002351-protein
Type	polypeptide
Organism	Clytia hemisphaerica (Jellyfish)
Sequence length	1060

Sequence

The following sequences are available for this feature:

polypeptide sequence

polypeptide sequence

>TCONS_00002351-protein ID=TCONS_00002351-protein|Name=TCONS_00002351-protein|organism=Clytia hemisphaerica|type=polypeptide|length=1060bp
MKVTLASLAKHNYWYEKEPNSTIDVICLLWNGMFIKLSNIRADLPLEKIK
EDLWSQRGKHSKEPKENYVFVVVSNNHGTEELVDEKLSLFDVKPVKPYLK
VTRKQGNEEIKKIKSKISMLIGHNISACNQEEVKEAQKNLSDMCNRISIE
RGKSSWYRRAIYTYPPDFEEDSKLPRFLEEKFPNKRIHISVSVLKNSSNV
FDVEYSIKPLELIEKALRKRAQTLRVDYKDDPDQYMLKVLGSESYFLGNI
VFENDQECYKEIPLIQYKYIREALYWDRRPSLIVMKREDMDICKLSSTNQ
DYPPALLPKNRQSKRNKFINLWDLSPKTMFKVKIKSALDLNSGKLWEKVQ
CGIFHGGDEVCETRSTSRIQGSSPVWNEFLNFDLPVCDIPRMARLCFCIV
GYENKKKGQAVPLAWVNMPLFNYKGFLHTGSFRIYCWQHSKKSNRTAANL
TFNPLGTVMNSNESGPCLAFELTEHDGKRPVVYPSEEDVYEKAANDITKG
TQESDGENILLVKGGKQHKEQIEDIIKRDSLAPMFEQDKELLWRLRAECC
LEYPESLPKLLQCVKWNNKEQVAQIHFLLQSWNCRTLEVEIALELLDYKF
PDLKVRQRAVEVLNNISDNQLEMYLLHLVQALKYESYLDSPLARYLLKRA
LNNRRIGHYLFWHLKADVGNTEHSLQFGLLLELYCFGAVEHIDSLYKQVE
LMKKLKTVSSILIDIKEDKDKIDRMKDCFKGFSRFFQDLVSPLDPRYRLK
QLRVEKCNMMSSKKKPFWLVFENFDDKADDIFIIFKSGDDLRQDMLTLLS
LQLMDSVWKSAGLDYGIIPYRCLSTGPSIGLIQVVTNSKTIASIQSKSGV
IRGALSASVLYNWLEANSTKVTNTDQVSPLTGEQKLELLTRNFTRSLVGY
SVGMYVLGVGDRHNDNIMMKEDTGQLFHIDFGHFLGNFKTKFGIQRERAK
FVLTSDMCYVIAKDGADDASSRFKSMCLEAFSCLRERGNLFITVFAMLLS
SGLPELRRPTDIDYLRDSLALLKDEADAQKHFIEIFEEALNKGGWTTIQF
LIHNIRHHRN

Run BLAST on NCBI

Gene-mRNA-Prot

This polypeptide comes from the following gene feature:


Feature Name	Unique Name	Species	Type
XLOC_001238	XLOC_001238	Clytia hemisphaerica	gene

This polypeptide derives from the following transcript feature(s):


Feature Name	Unique Name	Species	Type
TCONS_00002351	TCONS_00002351	Clytia hemisphaerica	transcript

Annotated Terms

The following terms have been associated with this polypeptide:

Vocabulary: **INTERPRO**
Term	Definition
IPR000403	PI3/4_kinase_cat_dom
IPR001263	PInositide-3_kin_accessory_dom
IPR002420	PI3K_C2_dom
IPR000341	PI3K_Ras-bd_dom
IPR000008	C2_dom
IPR003113	PI3K_adapt-bd_dom
IPR018936	PI3/4_kinase_CS
IPR016024	ARM-type_fold
IPR011009	Kinase-like_dom
IPR029071	Ubiquitin-rel_dom

Vocabulary: **Molecular Function**
Term	Definition
GO:0016301	kinase activity
GO:0005488	binding

GO Annotation

GO Assignments

This polypeptide is annotated with the following GO terms.

Category	Term Accession	Term Name
molecular_function	GO:0005488	binding
molecular_function	GO:0016301	kinase activity

InterPro

Analysis Name: InterPro Annotations of C. hemisphaerica v1.0
Date Performed: 2017-06-01


IPR Term	IPR Description	Source	Source Term	Source Description	Alignment
IPR000403	Phosphatidylinositol 3-/4-kinase, catalytic domain	SMART	SM00146	pi3k_hr1_6	coord: 782..1058 e-value: 2.7E-89 score: 312.7
IPR000403	Phosphatidylinositol 3-/4-kinase, catalytic domain	GENE3D	1.10.1070.11		coord: 837..1045 e-value: 4.2E-49 score: 166.3
IPR000403	Phosphatidylinositol 3-/4-kinase, catalytic domain	PFAM	PF00454	PI3_PI4_kinase	coord: 783..1006 e-value: 1.5E-39 score: 136.2
IPR000403	Phosphatidylinositol 3-/4-kinase, catalytic domain	PROSITE	PS50290	PI3_4_KINASE_3	coord: 781..1041 score: 58.319
IPR001263	Phosphoinositide 3-kinase, accessory (PIK) domain	SMART	SM00145	pi3k_hr2_4	coord: 512..697 e-value: 5.9E-70 score: 248.4
IPR001263	Phosphoinositide 3-kinase, accessory (PIK) domain	PFAM	PF00613	PI3Ka	coord: 513..695 e-value: 1.3E-50 score: 171.2
IPR001263	Phosphoinositide 3-kinase, accessory (PIK) domain	PROSITE	PS51545	PIK_HELICAL	coord: 508..687 score: 32.961
IPR002420	Phosphatidylinositol 3-kinase, C2 domain	SMART	SM00142	pi3k_hr3_6	coord: 316..421 e-value: 3.6E-13 score: 59.8
IPR002420	Phosphatidylinositol 3-kinase, C2 domain	PFAM	PF00792	PI3K_C2	coord: 349..448 e-value: 5.2E-24 score: 84.8
IPR002420	Phosphatidylinositol 3-kinase, C2 domain	PROSITE	PS51547	PI3K_C2	coord: 326..480 score: 33.069
IPR000341	Phosphatidylinositol 3-kinase Ras-binding (PI3K RBD) domain	SMART	SM00144	pi3k_ras_2	coord: 170..289 e-value: 2.6E-5 score: 33.6
IPR000341	Phosphatidylinositol 3-kinase Ras-binding (PI3K RBD) domain	PFAM	PF00794	PI3K_rbd	coord: 173..288 e-value: 1.3E-10 score: 41.3
IPR000341	Phosphatidylinositol 3-kinase Ras-binding (PI3K RBD) domain	PROSITE	PS51546	PI3K_RBD	coord: 184..286 score: 22.799
IPR000008	C2 domain	GENE3D	2.60.40.150		coord: 327..484 e-value: 4.2E-33 score: 113.6
IPR000008	C2 domain	SUPERFAMILY	49562	C2 domain (Calcium/lipid-binding domain, CaLB)	coord: 319..445
None	No IPR available	GENE3D	3.10.20.90		coord: 22..105 e-value: 6.7E-16 score: 57.5
None	No IPR available	GENE3D	3.30.1010.10		coord: 689..834 e-value: 2.0E-33 score: 115.1
None	No IPR available	GENE3D	1.25.40.70		coord: 498..688 e-value: 4.0E-54 score: 182.7
None	No IPR available	PIRSF	PIRSF000587	PI3K_Vps34	coord: 313..464 e-value: 9.0E-5 score: 18.6 coord: 485..639 e-value: 6.2E-21 score: 72.1 coord: 636..1049 e-value: 1.0E-56 score: 190.5
None	No IPR available	GENE3D	3.10.20.90		coord: 106..319 e-value: 1.2E-33 score: 115.9
IPR003113	Phosphatidylinositol 3-kinase adaptor-binding (PI3K ABD) domain	PFAM	PF02192	PI3K_p85B	coord: 42..107 e-value: 1.5E-10 score: 40.6
IPR018936	Phosphatidylinositol 3/4-kinase, conserved site	PROSITE	PS00916	PI3_4_KINASE_2	coord: 896..916
IPR016024	Armadillo-type fold	SUPERFAMILY	48371	ARM repeat	coord: 516..687
IPR011009	Protein kinase-like domain	SUPERFAMILY	56112	Protein kinase-like (PK-like)	coord: 693..1047
IPR029071	Ubiquitin-related domain	SUPERFAMILY	54236	Ubiquitin-like	coord: 106..291

Blast

[Close]

BLAST of TCONS_00002351-protein vs. Swiss-Prot (Human)
Match: PK3CB (Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform OS=Homo sapiens GN=PIK3CB PE=1 SV=1)

HSP 1 Score: 637.106 bits (1642), Expect = 0.000e+0
Identity = 420/1097 (38.29%), Postives = 601/1097 (54.79%), Query Frame = 0

Query:   20 NSTIDVICLLWNGMFIKLSNIRADLPLEKIKEDLWSQRGKHSK----EPKENYVFVVVSNNHGTEELVDEKLSLFDVKPVKPYLKVTRKQGNEEIKKIKSKISMLIG---HNISACNQEEVKEAQKNLSDMCNRISIERGKSSWYRRAIYTYPPDFEEDSKLPRFLEEKFPNKRIHISVSVLKNSSNVFDVEYS--IKPLELIEKALRKRAQTLRVDYKDD---PDQYMLKVLGSESYFLGNIVFENDQECYKEIPLIQYKYIREALYWDRRPSLIVMKREDMDICKLSSTNQDYPPAL----------LPKNRQSKRNKFI-NLWDLSPKTMFKVKIKSALDLNSGKLWE-KVQCGIFHGGDEVCETRSTSRIQGSSP-VWNEFLNFDLPVCDIPRMARLCFCIVG------------------YENKKKGQAV--PLAWVNMPLFNYKGFLHTGSFRIYCWQHSKKSNRTAANLTFNPLGTVMNS--NESGPCLAFELTEHDGKRPVVYPSEEDVYEKAANDITKGTQESDGENILLVKGGKQHKEQIEDIIKRDSLAPMFEQDKELLWRLRAECCLEYPESLPKLLQCVKWNNKEQVAQIHFLLQSWNCRTLEVEIALELLDYKFPDLKVRQRAVEVLNNISDNQLEMYLLHLVQALKYESYLDSPLARYLLKRALNNRRIGHYLFWHLKADVGNTEHSLQFGLLLELYCFGAVEHIDSLYKQVELMKKLKTVSSILIDIKEDKDKIDR------MKDCFK--GFSRFFQDLVSPLDPRYRLKQLRVEKCNMMSSKKKPFWLVFENFDDKADDIFIIFKSGDDLRQDMLTLLSLQLMDSVWKSAGLDYGIIPYRCLSTGPSIGLIQVVTNSKTIASIQSKSGVI--RGALSASVLYNWL-EANSTKVTNTDQVSPLTGEQKLELLTRNFTRSLVGYSVGMYVLGVGDRHNDNIMMKEDTGQLFHIDFGHFLGNFKTKFGIQRERAKFVLTSDMCYVI--AKDGADDASSRFKSMCLEAFSCLRERGNLFITVFAMLLSSGLPELRRPTDIDYLRDSLALLKDEADAQKHFIEIFEEALNKGGWTTIQFLIHNIR 1056
            + +I V  LL  G++I+L   R +  +  IK+ LW Q   +         ++Y+F  V+     EEL DE   L DV+P  P LK+  +  +   +K+ SKI +LIG   H   +    EV E ++ +        +     SW      TYPP  E +  +P  LE+K    ++ ++V   +N  +VF  + S  + P+++ E A++KR   L +  K+D   P  Y+L+V G   Y  G            + PLIQ++YIR  +     P  I++     + CK+    +    A+          LP     K+ + I ++W+      F++ +     LN+ +  +  V+ G+FHG + +C+T  +S + G +  +WNE L FD+ +CD+PRMARLCF +                    Y+  +K   V  P+AWVN  +F++KG L TG   ++ W     S         NP+GTV  +   E+   L  +  E + K+P  YP  + + EKAA         SD  N+   +GGK+    +++I+ RD L+ + E + +L+W LR +C   +P+SLPKLL  +KWN  E VAQ+  LLQ W    L    ALELLD+ +PD  VR+ AV  L  +SD +L  YLL LVQ LKYE +LD  L+R+LL+RAL NRRIG +LFWHL+++V     S+QFG++LE YC G+V H+  L KQVE + KLKT++S+   IK +  K++R      M  C K   +     DL SPL+P   L +L VEKC  M SK KP WLV+ N     D + +IFK+GDDLRQDMLTL  L+LMD +WK AGLD  ++PY CL+TG   GLI+VV+ S+TIA IQ  S  +    A +   L NWL E NS                 L+     FT S  GY V  YVLG+GDRH+DNIM+K+ TGQLFHIDFGH LGNFK+KFGI+RER  F+LT D  +VI   K G  +   RF+  C +A+  LR  GNLFIT+FA++L++GLPEL    DI YL+DSLAL K E +A K F + F+EAL +   T + ++ H +R
Sbjct:   27 DGSIPVDFLLPTGIYIQLEVPR-EATISYIKQMLWKQVHNYPMFNLLMDIDSYMFACVNQTAVYEELEDETRRLCDVRPFLPVLKLVTRSCDPG-EKLDSKIGVLIGKGLHEFDSLKDPEVNEFRRKMRKFSEEKILSLVGLSWMDWLKQTYPP--EHEPSIPENLEDKLYGGKLIVAVH-FENCQDVFSFQVSPNMNPIKVNELAIQKR---LTIHGKEDEVSPYDYVLQVSGRVEYVFG------------DHPLIQFQYIRNCVMNRALPHFILV-----ECCKIKKMYEQEMIAIEAAINRNSSNLPLPLPPKKTRIISHVWE--NNNPFQIVLVKGNKLNTEETVKVHVRAGLFHGTELLCKTIVSSEVSGKNDHIWNEPLEFDINICDLPRMARLCFAVYAVLDKVKTKKSTKTINPSKYQTIRKAGKVHYPVAWVNTMVFDFKGQLRTGDIILHSWS----SFPDELEEMLNPMGTVQTNPYTENATALHVKFPE-NKKQPYYYPPFDKIIEKAAE-----IASSDSANVS-SRGGKKFLPVLKEILDRDPLSQLCENEMDLIWTLRQDCREIFPQSLPKLLLSIKWNKLEDVAQLQALLQIWP--KLPPREALELLDFNYPDQYVREYAVGCLRQMSDEELSQYLLQLVQVLKYEPFLDCALSRFLLERALGNRRIGQFLFWHLRSEVHIPAVSVQFGVILEAYCRGSVGHMKVLSKQVEALNKLKTLNSL---IKLNAVKLNRAKGKEAMHTCLKQSAYREALSDLQSPLNPCVILSELYVEKCKYMDSKMKPLWLVYNNKVFGEDSVGVIFKNGDDLRQDMLTLQMLRLMDLLWKEAGLDLRMLPYGCLATGDRSGLIEVVSTSETIADIQLNSSNVAAAAAFNKDALLNWLKEYNSG--------------DDLDRAIEEFTLSCAGYCVASYVLGIGDRHSDNIMVKK-TGQLFHIDFGHILGNFKSKFGIKRERVPFILTYDFIHVIQQGKTGNTEKFGRFRQCCEDAYLILRRHGNLFITLFALMLTAGLPELTSVKDIQYLKDSLALGKSEEEALKQFKQKFDEALRESWTTKVNWMAHTVR 1065

The following BLAST results are available for this feature:

BLAST of TCONS_00002351-protein vs. Swiss-Prot (Human)

BLAST of TCONS_00002351-protein vs. Swiss-Prot (Human)
Analysis Date: 2018-01-31 (Blastp Clytia hemisphaerica v1.0 proteins vs SwissProt (Homo sapiens))
Total hits: 1


Match Name	E-value	Identity	Description
PK3CB	0.000e+0	38.29	Phosphatidylinositol 4,5-bisphosphate 3-kinase cat...	[more]

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TCONS_00002351-protein (polypeptide) - C. hemisphaerica