TCONS_00056027-protein (polypeptide) - C. hemisphaerica

Overview


Name	TCONS_00056027-protein
Unique Name	TCONS_00056027-protein
Type	polypeptide
Organism	Clytia hemisphaerica (Jellyfish)
Sequence length	2135

Sequence

The following sequences are available for this feature:

polypeptide sequence

polypeptide sequence

>TCONS_00056027-protein ID=TCONS_00056027-protein|Name=TCONS_00056027-protein|organism=Clytia hemisphaerica|type=polypeptide|length=2135bp
MNSSNALNNACQKGKLKKVKEILERNPTDVNVNAGVFGFTPLHEATSSGR
PDIIELLLEKGANVDSKSNGKYTPLHIAATIGDLKCIEVLLRYNADLRQE
DEFGKSPHKTAEVNKQRKAARLLKTEEVKKAIENNREFGKTVENIQPGVD
VTLNCFNECLVIAVKRNYHFAAGFISLREPDNMLESLKECLSTPSSKETA
AMLLACTAASKGDCEILQLLFCAETKEQISKQNVNAVILRRDFLPNKEMS
VADMIDLGEAANGIDHAFPVSMACSKKKFKAVNILLFMETYVSPLKKEAD
WHGLALSVLKEECIEKIITYKKLNLGWNHLTRLPSNMNRLANLVRLNLQK
NRLQNIPGYVFTLPALRNLNLSGNLIQKLPIVEWSPSLNILDLKDNLLIT
FPENIKGATIEYLNIANNKLETFPLGICSITTLRNLDISDNKDIRELPIE
LGYLSKLVDFTFKGLVIKDPPTNVQRPAKTLISHLRARLRAAEPYYCMKL
LIIGQAAQGKTTLMHRLKGDVNYSDDISTQGIDIQEIKLPRKAFGNQQTQ
FTFRVWDFAGQDDYYATHQCFLSRRSLYLLIWDSQELSNGVNGLKLWLDN
LTTRVPGATIIVIGTMLDKVPPGVLQKNFVPHMREAVENLFTSDARYYKI
NLAGVEFVSSNVKYKDYSKMMEGLRQLIYQVASEMEYCDPRNGKPTGDLI
MGEKIPHSYRLFEDRLRERQREKAQETKGIPILMRDEFMMLAKESPNNNE
KDRLHSEDIADVTKFLHNIGTILHYNDPNYDLKDMYFINPSWLCRLMSKI
ITVDAVHARIKNGILSIDDLKNFIIRDDIDFPNMFYNRYLRLLFRFQIAC
PIDSNRVLVPSKLPEGSARIVKEPAQTTLLIRRHTFHCIPFGFWERFVSR
LLLFMRDMLVVSSSKKTLDHVQLATMMTSTKAEDNSKTKQQQNVEDLLHQ
QEDEDEDEEDTLNLSINQPPKAGIVYVNADTNMSPPPQDDEGSPNLPFRS
MLSLNGVEYDENSTSTSAMSTVNSDVSSTIPSLGSIYQTSHDETSSVTSG
TFSSYGSRAPSLNPNTSSDTGHVQDDAKPLSSSLDEESESQLTSDGERCS
PEPPNEMTSSSPLQSSVSMITVIDLEASENETSPCMPQPSEVIDKREKEF
LSQNSDIDVAEMEDSLLQEEENNNNNPLILTEERIDETNDGGVTNHIGVE
LLNETTESTHIVNDEKTTSSGNHLQYSPSLSEEDSPNETFEENPRDPVDM
ATTGESSKRTHYSESDEACFGFQKPSKEQDFCEVLNEFPDISHLFDQGII
TCWKTGIIFDDPKLFFSVRKLKNKYSSSEEIIETKVSNSSIGHRVLGYII
DHIRTLIKEWYPGLSGNDGERAFVNQFAACPVCIQLGIRKPYMFDIKDAF
AKIYIARNGDKCLSCEAEKRHSPQVVDVEQLCPELLFKDLSEDLQIARSK
LEFEENEDYLIGNGAFGKVYRGNYIISDDKQIEVAIKFYNFEDYVLSAQD
VFHDIRQEIFVLSKLREHKFIVRFVGFLTEPRLSALMELACHGNLKDALY
DQSGKKKEINRVVLFRVVKQIASALDFMHKRRIIHRDIKSDNILVFQIDH
QTGDIHIKLTDFGTANFLTPDGMKFVAGTPGFMAPEMFEFISSDEYTIKV
DIYSFAMVIGEMINGRRPFHDIQYEHQIPQALRDRDRPSYVDTKESLYGL
LPLTDLMTKMWKHESTKRPTAHQVLTQSQHPAFQLFYGKRTLEPVQNPKH
LCAVPSTHNLWAVCDHLSGVSVIILNMKTSEVKTVWNIDGQAYGMDSYNP
MHVVLITETHIAITLLGTADDQIRIFTTDGKNPSHEVIEDNHIKAMAVHK
DHVYVGYQSGQLGRVTIKNFLKGKLTKEGVQVLINQDRPVMSMVFNEKYV
IASSGGYVYQYPCAFVKDEKTDRLKRLHHQQRILDMKLLSDGENFVAQFQ
CASEVQIVNTNSLEVLQKIDVEDKVRELKPNCDPWDHRVWTLCPAHDTLW
LGMGSGHIFIYDISDPKNKTPELLTYFQPYKFELRKLCLWKNDTSKDLYG
VEYIMASTGKELNDEAFGFNPLCKLTTDFPPFDERISDKKDSITSSTASF
SEEVERKKEEKMERKTMLFWYAPSAKLLRNLLLET

Run BLAST on NCBI

Gene-mRNA-Prot

This polypeptide comes from the following gene feature:


Feature Name	Unique Name	Species	Type
XLOC_035252	XLOC_035252	Clytia hemisphaerica	gene

This polypeptide derives from the following transcript feature(s):


Feature Name	Unique Name	Species	Type
TCONS_00056027	TCONS_00056027	Clytia hemisphaerica	transcript

Annotated Terms

The following terms have been associated with this polypeptide:

Vocabulary: **INTERPRO**
Term	Definition
IPR002110	Ankyrin_rpt
IPR000719	Prot_kinase_dom
IPR003591	Leu-rich_rpt_typical-subtyp
IPR015943	WD40/YVTN_repeat-like_dom
IPR032675	L_dom-like
IPR020683	Ankyrin_rpt-contain_dom
IPR013684	MIRO-like
IPR032171	COR
IPR017441	Protein_kinase_ATP_BS
IPR008271	Ser/Thr_kinase_AS
IPR001611	Leu-rich_rpt
IPR020859	ROC_dom
IPR011009	Kinase-like_dom
IPR011044	Quino_amine_DH_bsu
IPR027417	P-loop_NTPase

Vocabulary: **Molecular Function**
Term	Definition
GO:0005515	protein binding
GO:0004672	protein kinase activity
GO:0005524	ATP binding
GO:0005525	GTP binding

Vocabulary: **Biological Process**
Term	Definition
GO:0006468	protein phosphorylation
GO:0007264	small GTPase mediated signal transduction

GO Annotation

GO Assignments

This polypeptide is annotated with the following GO terms.

Category	Term Accession	Term Name
biological_process	GO:0006468	protein phosphorylation
biological_process	GO:0007264	small GTPase mediated signal transduction
molecular_function	GO:0005524	ATP binding
molecular_function	GO:0005525	GTP binding
molecular_function	GO:0005515	protein binding
molecular_function	GO:0004672	protein kinase activity

InterPro

Analysis Name: InterPro Annotations of C. hemisphaerica v1.0
Date Performed: 2017-06-01


IPR Term	IPR Description	Source	Source Term	Source Description	Alignment
None	No IPR available	COILS	Coil	Coil	coord: 1437..1457
None	No IPR available	PRINTS	PR00449	RASTRNSFRMNG	coord: 498..519 score: 34.16 coord: 544..566 score: 26.71 coord: 606..619 score: 24.17
None	No IPR available	SMART	SM00175	rab_sub_5	coord: 498..651 e-value: 0.0044 score: -71.3
None	No IPR available	GENE3D	3.30.200.20		coord: 1440..1546 e-value: 2.8E-13 score: 49.3
None	No IPR available	GENE3D	1.10.510.10		coord: 1547..1743 e-value: 1.7E-43 score: 147.6
None	No IPR available	GENE3D	3.40.50.300		coord: 499..952 e-value: 1.9E-16 score: 59.5
None	No IPR available	MOBIDB_LITE	mobidb-lite	disorder_prediction	coord: 1211..1262
None	No IPR available	MOBIDB_LITE	mobidb-lite	disorder_prediction	coord: 977..1000
None	No IPR available	MOBIDB_LITE	mobidb-lite	disorder_prediction	coord: 1036..1116
None	No IPR available	CDD	cd00204	ANK	coord: 5..123 e-value: 8.17314E-24 score: 99.3802
None	No IPR available	CDD	cd00204	ANK	coord: 65..220 e-value: 9.90532E-7 score: 48.1486
IPR002110	Ankyrin repeat	SMART	SM00248	ANK_2a	coord: 37..66 e-value: 4.3E-6 score: 36.2 coord: 2..32 e-value: 27.0 score: 13.7 coord: 70..99 e-value: 0.0014 score: 27.9
IPR002110	Ankyrin repeat	PROSITE	PS50088	ANK_REPEAT	coord: 70..102 score: 11.968
IPR002110	Ankyrin repeat	PROSITE	PS50088	ANK_REPEAT	coord: 37..69 score: 14.639
IPR000719	Protein kinase domain	SMART	SM00220	serkin_6	coord: 1455..1733 e-value: 5.2E-50 score: 182.1
IPR000719	Protein kinase domain	PFAM	PF00069	Pkinase	coord: 1460..1727 e-value: 1.2E-46 score: 159.1
IPR000719	Protein kinase domain	PROSITE	PS50011	PROTEIN_KINASE_DOM	coord: 1455..1733 score: 39.722
IPR003591	Leucine-rich repeat, typical subtype	SMART	SM00369	LRR_typ_2	coord: 364..386 e-value: 110.0 score: 4.6 coord: 340..363 e-value: 0.06 score: 22.5
IPR015943	WD40/YVTN repeat-like-containing domain	GENE3D	2.130.10.10		coord: 1744..2049 e-value: 1.1E-13 score: 50.3
IPR032675	Leucine-rich repeat domain, L domain-like	GENE3D	3.80.10.10		coord: 266..498 e-value: 8.8E-28 score: 96.3
IPR032675	Leucine-rich repeat domain, L domain-like	SUPERFAMILY	52058	L domain-like	coord: 300..472
IPR020683	Ankyrin repeat-containing domain	PFAM	PF12796	Ank_2	coord: 8..101 e-value: 4.7E-14 score: 52.6
IPR020683	Ankyrin repeat-containing domain	GENE3D	1.25.40.20		coord: 1..233 e-value: 8.3E-31 score: 106.5
IPR020683	Ankyrin repeat-containing domain	PROSITE	PS50297	ANK_REP_REGION	coord: 2..135 score: 30.104
IPR020683	Ankyrin repeat-containing domain	SUPERFAMILY	48403	Ankyrin repeat	coord: 3..128
IPR013684	Mitochondrial Rho-like	PFAM	PF08477	Roc	coord: 499..618 e-value: 1.1E-23 score: 83.6
IPR032171	C-terminal of Roc (COR) domain	PFAM	PF16095	COR	coord: 706..908 e-value: 8.5E-21 score: 74.6
IPR017441	Protein kinase, ATP binding site	PROSITE	PS00107	PROTEIN_KINASE_ATP	coord: 1461..1487
IPR008271	Serine/threonine-protein kinase, active site	PROSITE	PS00108	PROTEIN_KINASE_ST	coord: 1583..1595
IPR001611	Leucine-rich repeat	PROSITE	PS51450	LRR	coord: 432..455 score: 6.049
IPR001611	Leucine-rich repeat	PROSITE	PS51450	LRR	coord: 409..430 score: 5.132
IPR001611	Leucine-rich repeat	PROSITE	PS51450	LRR	coord: 342..363 score: 7.604
IPR001611	Leucine-rich repeat	PROSITE	PS51450	LRR	coord: 365..386 score: 7.673
IPR001611	Leucine-rich repeat	PROSITE	PS51450	LRR	coord: 319..340 score: 5.587
IPR001611	Leucine-rich repeat	PROSITE	PS51450	LRR	coord: 387..408 score: 5.409
IPR020859	Roc domain	PROSITE	PS51424	ROC	coord: 491..685 score: 33.378
IPR011009	Protein kinase-like domain	SUPERFAMILY	56112	Protein kinase-like (PK-like)	coord: 1460..1726
IPR011044	Quinoprotein amine dehydrogenase, beta chain-like	SUPERFAMILY	50969	YVTN repeat-like/Quinoprotein amine dehydrogenase	coord: 1757..2019
IPR027417	P-loop containing nucleoside triphosphate hydrolase	SUPERFAMILY	52540	P-loop containing nucleoside triphosphate hydrolases	coord: 496..624

Blast

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BLAST of TCONS_00056027-protein vs. Swiss-Prot (Human)
Match: LRRK2 (Leucine-rich repeat serine/threonine-protein kinase 2 OS=Homo sapiens GN=LRRK2 PE=1 SV=2)

HSP 1 Score: 250.366 bits (638), Expect = 2.223e-66
Identity = 183/626 (29.23%), Postives = 305/626 (48.72%), Query Frame = 0

Query:  321 KKLNLGWNHLTRLPSN--------------MNRLA-------NLVRLNLQKNRLQNIPGYVFTLPALRNLNLSGNLIQKLPIVEWSPSLNILDL-----KDNLLITFPENIKGATIEYLNIANNKLETFPLGICSITTLRNLDISDNKDIRELPIELGYLSKLVDFTFKGLVIKDPPTNVQRPAKTLISHLRARLRAAEPYYCMKLLIIGQAAQGKTTLMHRL----KGDVNYSDDISTQGIDIQEIKLPRKAFGNQQTQFTFRVWDFAGQDDYYATHQCFLSRRSLYLLIWDSQELSNGVNGLKLWLDNLTTRVPGATIIVIGTMLD------------KVPPGVLQKNFVPHMREAVENLFTSDARYYKINLAGVEFVSSNVKYKDYSKMMEGLRQLIYQVASEMEYCDPRNGKPTGDLIMGEKIPHSYRLFEDRLRERQREKAQETKGIPILMRDEFMMLAKESPNNNEKDRLHSEDIADVTKFLHNIGTILHYNDPNYDLKDMYFINPSWLCRLMSKIITVDAVHA-RIKNGILSIDDLKNFIIRDDIDFPNMFYNRYLRLLFRFQIACPIDSNRVLVPSKLPEGSARI-VKEPAQTTLLIRRHTFHCIPFGFWERFVSRLL 902
            K LNL  NH++ L  N              MN LA       ++  L L +N+   IP  +  LP LR+L++S N IQ LP      SLN+ +L     + ++L    +    + +E L++++NKL+  P  I  +  L +LD+S N ++R  P E+G LSK+ D     L +     ++   AK +I  L+ RL+ A PY  MKL+I+G    GKTTL+ +L    K D+      +T GID+++   P +    ++      VWDFAG++++Y+TH  F+++R+LYL ++D  +    V+ +K WL N+  R   + +I++GT LD            K+   +L K   P +R+           Y+ +N              + S  +  LR+ I          +  N K    L++G+ IP  Y   E  +   ++    E    P++ R   + L +E+     + +L   ++     FL+  G +LH+ DP   L D+YF+ P WLC++M++I+TV      +   GI+S  D++ F+ +    FP  + ++Y +LL +FQIA PI    +LVPS L +    I +     + ++IR +     P GFW R ++RLL
Sbjct: 1132 KILNLSKNHISSLSENFLEACPKVESFSARMNFLAAMPFLPPSMTILKLSQNKFSCIPEAILNLPHLRSLDMSSNDIQYLPGPAHWKSLNLRELLFSHNQISILDLSEKAYLWSRVEKLHLSHNKLKEIPPEIGCLENLTSLDVSYNLELRSFPNEMGKLSKIWDLPLDELHLNFDFKHIGCKAKDIIRFLQQRLKKAVPYNRMKLMIVGNTGSGKTTLLQQLMKTKKSDLGMQS--ATVGIDVKD--WPIQIRDKRKRDLVLNVWDFAGREEFYSTHPHFMTQRALYLAVYDLSKGQAEVDAMKPWLFNIKARASSSPVILVGTHLDVSDEKQRKACMSKITKELLNKRGFPAIRD-----------YHFVNAT------------EESDALAKLRKTIIN--------ESLNFKIRDQLVVGQLIPDCYVELEKIILSERKNVPIE---FPVIDRKRLLQLVREN-----QLQLDENELPHAVHFLNESGVLLHFQDPALQLSDLYFVEPKWLCKIMAQILTVKVEGCPKHPKGIISRRDVEKFLSKKR-KFPKNYMSQYFKLLEKFQIALPIGEEYLLVPSSLSDHRPVIELPHCENSEIIIRLYEMPYFPMGFWSRLINRLL 1713

HSP 2 Score: 166.392 bits (420), Expect = 8.593e-41
Identity = 185/771 (23.99%), Postives = 335/771 (43.45%), Query Frame = 0

Query: 1303 WKTGIIFDDPKLFFSVRKLKNKYSSSEEIIETKVSNSSIGHRVLGYIIDHIRTLIKEWYPGLSGND--GE-RAFVNQFAACPVCIQLGIRKPYMFDIKDAFAKIYI------ARNGDKCLSCEAEKRHSPQVVDVEQLCPELLFKDLSEDLQIARSKLEFEENEDYLIGNGAFGKVYRGNYIISDDKQIEVAIKFYNFEDYVLSAQDVFHDIRQEIFVLSKLREHKFIVRFVGFLTEPRLSALMELACHGNLKDALYDQSGKKKEINRVVLFRVVKQIASALDFMHKRRIIHRDIKSDNILVFQIDHQTGDIHIKLTDFGTANFLTPDGMKFVAGTPGFMAPEMFEFISSDEYTIKVDIYSFAMVI-------GEMINGRR---PFHDIQYEHQIPQALRDRDRPSYVDTKESLYGLLP---LTDLMTKMWKHESTKRPTAHQVLTQSQHPAFQLFYGKRTLEPVQNPKHLCAVPSTHN-----LWAVCDHLSGVSVIILNMKTSEVKTVWNIDGQAYGMDSYNPMHVVLITETHIAI-----TLLGTADDQIRIFTTDGKNPSH--EVIED-------NHIKAMAVHKDHVYVGYQSGQLGRVTIKNF-LKGKLTKEGVQVLINQDRPVMSMV----FNEKYVI-ASSGGYVYQYPCAFVKDEKTD-RLKRLHHQQRILDMKLLS---DGENFVAQFQCASEVQIVNTNSLEVLQKIDVEDKVRE--LKPNCD-----PWDHRVWTLCPAHDT-LWLGMGSGHIFIYDIS 2014
            W+ GI  +     + +   +   +  E  ++  V +   G  +LG ++DHI +L++EW+PGL   D  GE    + ++A             Y F+  +   KI +      A  GD  ++ +  +   P    + Q+ P+L+  DL  ++ +   +LEFE+  ++L+G+G+FG VYR  Y     +  EVA+K +N              +RQE+ VL  L  H  ++  +     PR+  +MELA  G+L D L  Q   K  + R +  R+   +A  L ++H   II+RD+K  N+L+F + +    I  K+ D+G A +    G+K   GTPGF APE+     +  Y  + D+YSF +++       G ++ G +    F +++ + ++P  +++             YG  P   +  L+ +  K    +RPT+ QV     + A  +   +R L P +N    C V + HN     +W  C H     +  L++ T           + Y  +      ++ +   H+ +      + GT    + +  T+     H  E + D       N     +  K+ + VG   G+L     K   LKG    + + +  N   P+M +       E+ V+    G  ++ +   F   +  + R  +L       D  +++   D   ++A+ Q +  V++ +  + ++   ID    +RE  +K N +      +  RV TLC   +T LW+G G GHI + D+S
Sbjct: 1734 WRQGIYLNWSPEAYCLVGSEVLDNHPESFLKITVPSCRKGCILLGQVVDHIDSLMEEWFPGLLEIDICGEGETLLKKWAL------------YSFNDGEEHQKILLDDLMKKAEEGDLLVNPDQPRLTIP----ISQIAPDLILADLPRNIMLNNDELEFEQAPEFLLGDGSFGSVYRAAY-----EGEEVAVKIFN-------KHTSLRLLRQELVVLCHLH-HPSLISLLAAGIRPRM-LVMELASKGSL-DRLLQQD--KASLTRTLQHRIALHVADGLRYLHSAMIIYRDLKPHNVLLFTL-YPNAAIIAKIADYGIAQYCCRMGIKTSEGTPGFRAPEVAR--GNVIYNQQADVYSFGLLLYDILTTGGRIVEGLKFPNEFDELEIQGKLPDPVKE-------------YGCAPWPMVEKLIKQCLKENPQERPTSAQVF-DILNSAELVCLTRRILLP-KNVIVECMVATHHNSRNASIWLGCGHTDRGQLSFLDLNT-----------EGYTSEEVADSRILCLALVHLPVEKESWIVSGTQSGTLLVINTEDGKKRHTLEKMTDSVTCLYCNSFSKQSKQKNFLLVGTADGKLAIFEDKTVKLKGAAPLKILNI-GNVSTPLMCLSESTNSTERNVMWGGCGTKIFSFSNDFTIQKLIETRTSQLFSYAAFSDSNIITVVVDTALYIAK-QNSPVVEVWDKKTEKLCGLIDCVHFLREVMVKENKESKHKMSYSGRVKTLCLQKNTALWIGTGGGHILLLDLS 2440

The following BLAST results are available for this feature:

BLAST of TCONS_00056027-protein vs. Swiss-Prot (Human)

BLAST of TCONS_00056027-protein vs. Swiss-Prot (Human)
Analysis Date: 2018-01-31 (Blastp Clytia hemisphaerica v1.0 proteins vs SwissProt (Homo sapiens))
Total hits: 1


Match Name	E-value	Identity	Description
LRRK2	2.223e-66	29.23	Leucine-rich repeat serine/threonine-protein kinas...	[more]

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TCONS_00056027-protein (polypeptide) - C. hemisphaerica