Isocitrate/isopropylmalate dehydrogenase (polypeptide) - C. hemisphaerica

Overview
NameIsocitrate/isopropylmalate dehydrogenase
Unique NameTCONS_00059516-protein
Typepolypeptide
OrganismClytia hemisphaerica (Jellyfish)
Sequence length389

Sequence
The following sequences are available for this feature:

polypeptide sequence

>TCONS_00059516-protein ID=TCONS_00059516-protein|Name=Isocitrate/isopropylmalate dehydrogenase|organism=Clytia hemisphaerica|type=polypeptide|length=389bp
MAANSVWKSLKPSRIQSVLRRSLHTSRPSSNEARKFVTYDDPVEGAERKL
VTLIPGDGVGPELAGAVKHVFSSVGVPVDWDEIYVSDIGNFGGETSLDKV
KLSMSKTGVGLKGALTTPSNILQHDQKSLNQNLRLELDLFANVVHCRSLP
GIKTRHENVDICIIREQTEGEYSSLEHESVPGVIEMIKVITRKKSERIAK
FAFDYAMKNGRKKVTCVHKANIMKLADGLFVESCQNIAEMYPKIKFEAMI
VDNTCMQLVSRPQQFDVMVLPNLYGSIVNNLGAGLVGGAGVVPGKSLSRD
FAIFEPGARHTYAQVAGRNIANPTAMLLTACDMLDHIHFLKHSRMIREAV
HKTIDDGKYLTLDVGGSCSLSLFINKVIENILLHSSFTL
Run BLAST on NCBI
Gene-mRNA-Prot
This polypeptide comes from the following gene feature:
Feature NameUnique NameSpeciesType
XLOC_037463XLOC_037463Clytia hemisphaericagene
This polypeptide derives from the following transcript feature(s):
Feature NameUnique NameSpeciesType
TCONS_00059516TCONS_00059516Clytia hemisphaericatranscript
Annotated Terms
The following terms have been associated with this polypeptide:
Vocabulary: INTERPRO
TermDefinition
IPR024084IsoPropMal-DH-like_dom
IPR004434Isocitrate_DH_NAD
IPR019818IsoCit/isopropylmalate_DH_CS
Vocabulary: Biological Process
TermDefinition
GO:0055114oxidation-reduction process
GO:0006099tricarboxylic acid cycle
Vocabulary: Molecular Function
TermDefinition
GO:0016616oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0004449isocitrate dehydrogenase (NAD+) activity
GO:0051287NAD binding
GO:0000287magnesium ion binding
GO Annotation
GO Assignments
This polypeptide is annotated with the following GO terms.
Category Term Accession Term Name
biological_process GO:0055114 oxidation-reduction process
biological_process GO:0006099 tricarboxylic acid cycle
molecular_function GO:0004449 isocitrate dehydrogenase (NAD+) activity
molecular_function GO:0000287 magnesium ion binding
molecular_function GO:0051287 NAD binding
molecular_function GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
InterPro
Analysis Name: InterPro Annotations of C. hemisphaerica v1.0
Date Performed: 2017-06-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR024084Isopropylmalate dehydrogenase-like domainSMARTSM01329Iso_dh_2coord: 50..377
e-value: 4.0E-133
score: 458.2
IPR024084Isopropylmalate dehydrogenase-like domainPFAMPF00180Iso_dhcoord: 51..369
e-value: 1.4E-70
score: 238.1
NoneNo IPR availableGENE3D3.40.718.10coord: 38..386
e-value: 3.1E-115
score: 384.6
NoneNo IPR availableSUPERFAMILY53659Isocitrate/Isopropylmalate dehydrogenase-likecoord: 39..381
IPR004434Isocitrate dehydrogenase NAD-dependentTIGRFAMTIGR00175TIGR00175coord: 48..381
e-value: 2.6E-148
score: 491.6
IPR019818Isocitrate/isopropylmalate dehydrogenase, conserved sitePROSITEPS00470IDH_IMDHcoord: 272..291

Blast
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BLAST of Isocitrate/isopropylmalate dehydrogenase vs. Swiss-Prot (Human)
Match: IDH3B (Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial OS=Homo sapiens GN=IDH3B PE=1 SV=2)

HSP 1 Score: 397.127 bits (1019), Expect = 2.314e-137
Identity = 197/328 (60.06%), Postives = 246/328 (75.00%), Query Frame = 0 
Query:   51 VTLIPGDGVGPELAGAVKHVFSSVGVPVDWDEIYVSDIGNFGGETSLDKVKLSMSKTGVGLKGALTTPSNILQHDQKSLNQNLRLELDLFANVVHCRSLPGIKTRHENVDICIIREQTEGEYSSLEHESVPGVIEMIKVITRKKSERIAKFAFDYAMKNGRKKVTCVHKANIMKLADGLFVESCQNIAEMYPKIKFEAMIVDNTCMQLVSRPQQFDVMVLPNLYGSIVNNLGAGLVGGAGVVPGKSLSRDFAIFEPGARHTYAQVAGRNIANPTAMLLTACDMLDHIHFLKHSRMIREAVHKTIDDGKYLTLDVGGSCSLSLFINKVI 378
            VT++PGDGVGPEL  AVK VF +  VPV++ E ++S++ N   E  L++V  SM +  V + G + TP    + +  S +  LR +LDLFANVVH +SLPG  TRH N+D+ IIREQTEGEYSSLEHES  GVIE +K++TR KS+RIAKFAFDYA K GR KVT VHKANIMKL DGLF++ C+ +AE+YPKIKFE MI+DN CMQLV  P QFDV+V+PNLYG+I++NL AGLVGGAGVVPG+S S ++A+FE GARH +AQ  GRNIANPTAMLL+A +ML H++   HS MI +AV K I  GK  T D+GG  + + FI  VI
Sbjct:   51 VTMLPGDGVGPELMHAVKEVFKAAAVPVEFQEHHLSEVQNMASEEKLEQVLSSMKENKVAIIGKIHTPME-YKGELASYDMRLRRKLDLFANVVHVKSLPGYMTRHNNLDLVIIREQTEGEYSSLEHESARGVIECLKIVTRAKSQRIAKFAFDYATKKGRGKVTAVHKANIMKLGDGLFLQCCEEVAELYPKIKFETMIIDNCCMQLVQNPYQFDVLVMPNLYGNIIDNLAAGLVGGAGVVPGESYSAEYAVFETGARHPFAQAVGRNIANPTAMLLSASNMLRHLNLEYHSSMIADAVKKVIKVGKVRTRDMGGYSTTTDFIKSVI 377
The following BLAST results are available for this feature:
BLAST of Isocitrate/isopropylmalate dehydrogenase vs. Swiss-Prot (Human)
Analysis Date: 2018-01-31 (Blastp Clytia hemisphaerica v1.0 proteins vs SwissProt (Homo sapiens))
Total hits: 1
Match NameE-valueIdentityDescription
IDH3B2.314e-13760.06Isocitrate dehydrogenase [NAD] subunit beta, mitoc... [more]
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