voltage-gated sodium channel Nav2.5 (polypeptide) - C. hemisphaerica

Overview


Name	voltage-gated sodium channel Nav2.5
Unique Name	TCONS_00052147-protein
Type	polypeptide
Organism	Clytia hemisphaerica (Jellyfish)
Sequence length	1161

Sequence

The following sequences are available for this feature:

polypeptide sequence

polypeptide sequence

>TCONS_00052147-protein ID=TCONS_00052147-protein|Name=voltage-gated sodium channel Nav2.5|organism=Clytia hemisphaerica|type=polypeptide|length=1161bp
MGQLLSTIAGSMGALGNVTVILGLIIYIFSVMGMQIFGSLYDKTKYKPCD
PDGEEFPRYNFENFGNSFMMIFRILCGKWIEPQWDLLDLTNIASIFFIFL
VFVIGRWVVLNLFLALLLSSFAGLNETSDEEDEEPKMTRIQKIIEWSKKI
RKKKNKANFNDMDENDEKKDLGDGENGNLDTKNLADGNIPDMHVEIYGKD
GMLMVDSNGNEPKMTEVNSDIDNNLKPILNNHDSDISKLQNGTTISNGDV
SRRRLSGSVDIEIPVSVAPTEGFSNGGLDNGMGKKENSLSSVKIEIQREK
TYIDDCLCSFCYACSCCNTSYLESPLRRFWHNSRHNMKMLIEHKYFEAVI
LFLIAFSSLTLVFEDVYLNEKEGLKDFLFYCNYFFAIIFTLEFLVKLFAL
GFVTYFTNFWNLLDVFIVAISLSSLFGDSGGNLKALRSLRGLRPLRAISR
FEGMKVVVNALVYSIPSIGNVLLVCVAFWLIFSIMGYNLFGGKFSRCLDE
NFKQLNISWVNNKTQCFDRIREGYNYTWKNRNINFDDAASGFLALFQTAT
LEGWFEAMADAYDARNIDEQPGYRVSYFNQMYFVVFILLGAFFILNLFIG
VIIDNFNRLKQQYEDGADGVSFFLTPGQRNWINTLKAASLKKPSRRLTRP
KSKWRGTLFDFIQTKYFEFFIMSVILLNMLSMMIQHYNQPREVDLALDYL
NYVFTGIFTIEAILRLTAMRLEYFKYGMNVFDFIIVVFSIAAIVMDAYNQ
NFIISPGLFRVVRVFRLGRLLRFFEGAKGIRKLLFTIVKSAPALSNIGTL
LFLITFIYAIMGMNLFGTIAENGAITQTTNFKTFGASMCVLFRISTAAGW
NAVLEGAMVQPPSCDPNMQGNCGNKLIAIIFFVTYIMVIVLIIINMYIAV
ILENFNQAQSQDEAGITEDDLEAYYATWEEFDPKATQFIKYSQLSDFIDA
LDGPLKVPKPNYWFLEQTDIPIKERYRCHCLDIMTALIKRALGDESCEES
EDLSIILKKVEDRYKKLFPLRTKENDVETTRERLKTENAAAKSIQRVFRR
HLLMDEINLISNAKNNIGLRARDKTINKIEQLVTVMWKTQKNNGANDDEE
EEDENEEIESGEENEVFEDDFVPLQPGGGGGVSIAVPTSTGGGGASGDEN
GVIENTQADMA

Run BLAST on NCBI

Gene-mRNA-Prot

This polypeptide comes from the following gene feature:


Feature Name	Unique Name	Species	Type
XLOC_033023	XLOC_033023	Clytia hemisphaerica	gene

This polypeptide derives from the following transcript feature(s):


Feature Name	Unique Name	Species	Type
TCONS_00052147	TCONS_00052147	Clytia hemisphaerica	transcript

Annotated Terms

The following terms have been associated with this polypeptide:

Vocabulary: **INTERPRO**
Term	Definition
IPR001696	Na_channel_asu
IPR005821	Ion_trans_dom

Vocabulary: **Molecular Function**
Term	Definition
GO:0005248	voltage-gated sodium channel activity
GO:0005216	ion channel activity

Vocabulary: **Cellular Component**
Term	Definition
GO:0001518	voltage-gated sodium channel complex
GO:0016020	membrane

Vocabulary: **Biological Process**
Term	Definition
GO:0006814	sodium ion transport
GO:0055085	transmembrane transport
GO:0006811	ion transport

GO Annotation

GO Assignments

This polypeptide is annotated with the following GO terms.

Category	Term Accession	Term Name
biological_process	GO:0006811	ion transport
biological_process	GO:0006814	sodium ion transport
biological_process	GO:0055085	transmembrane transport
cellular_component	GO:0016020	membrane
cellular_component	GO:0001518	voltage-gated sodium channel complex
molecular_function	GO:0005216	ion channel activity
molecular_function	GO:0005248	voltage-gated sodium channel activity

InterPro

Analysis Name: InterPro Annotations of C. hemisphaerica v1.0
Date Performed: 2017-06-01


IPR Term	IPR Description	Source	Source Term	Source Description	Alignment
None	No IPR available	COILS	Coil	Coil	coord: 1020..1040
None	No IPR available	GENE3D	1.10.238.10		coord: 917..1008 e-value: 1.3E-8 score: 34.2
None	No IPR available	GENE3D	1.10.287.70		coord: 1..125 e-value: 8.2E-13 score: 47.7 coord: 663..910 e-value: 2.3E-49 score: 167.3 coord: 342..611 e-value: 4.6E-55 score: 185.9
None	No IPR available	MOBIDB_LITE	mobidb-lite	disorder_prediction	coord: 157..185
None	No IPR available	MOBIDB_LITE	mobidb-lite	disorder_prediction	coord: 1090..1161
None	No IPR available	CDD	cd13433	Na_channel_gate	coord: 604..660 e-value: 2.17255E-17 score: 77.6051
None	No IPR available	SUPERFAMILY	81324	Voltage-gated potassium channels	coord: 343..493 coord: 531..608
None	No IPR available	SUPERFAMILY	81324	Voltage-gated potassium channels	coord: 664..907
IPR001696	Voltage gated sodium channel, alpha subunit	PRINTS	PR00170	NACHANNEL	coord: 919..932 score: 54.08 coord: 884..903 score: 63.06
IPR005821	Ion transport domain	PFAM	PF00520	Ion_trans	coord: 665..911 e-value: 1.1E-52 score: 178.7 coord: 343..612 e-value: 1.1E-61 score: 208.1 coord: 3..128 e-value: 1.5E-18 score: 66.9

Blast

[Close]

BLAST of voltage-gated sodium channel Nav2.5 vs. Swiss-Prot (Human)
Match: SCN2A (Sodium channel protein type 2 subunit alpha OS=Homo sapiens GN=SCN2A PE=1 SV=3)

HSP 1 Score: 744.962 bits (1922), Expect = 0.000e+0
Identity = 440/1095 (40.18%), Postives = 649/1095 (59.27%), Query Frame = 0

Query:    1 MGQLLSTIAGSMGALGNVTVILGLIIYIFSVMGMQIFGSLYDKTKYKPCDPDGEEFPRYNFENFGNSFMMIFRILCGKWIEPQWDLLDLTNIASIFFIFL-VFVIGRWVVLNLFLALLLSSFAGLNETSDEEDEEP-----KMTRIQKIIEWSK-KIRKKKNKANFNDMDENDEKKDLGDGENGNLDTKNLADGNIPDMHVEIYGKDGMLMVDSNGNEPKMTEVNSDIDNNLKPILNNHDSDISKLQNGT-----TISNGD-----VSRRRLSGSVDIEIPVSVAPTEGFSNGGLDNGMGKKENSLSSVKIE--IQREKTYIDDCLCSFCYACSCCNTSYLESPLRRFWHNSRHNMKMLIEHKYFEAVILFLIAFSSLTLVFEDVYLNEKEGLKDFLFYCNYFFAIIFTLEFLVKLFALGFVTYFTNFWNLLDVFIVAISLSSLFGDSGG-----NLKALRSLRGLRPLRAISRFEGMKVVVNALVYSIPSIGNVLLVCVAFWLIFSIMGYNLFGGKFSRCLDENFKQL-NISWVNNKTQCFDRIREGYNYTWKNRNINFDDAASGFLALFQTATLEGWFEAMADAYDARNIDEQPGYRVSYFNQMYFVVFILLGAFFILNLFIGVIIDNFNRLKQQYEDGADGVSFFLTPGQRNWINTLKAASLKKPSRRLTRPKSKWRGTLFDFIQTKYFEFFIMSVILLNMLSMMIQHYNQPREVDLALDYLNYVFTGIFTIEAILRLTAMRLEYFKYGMNVFDFIIVVFSIAAIVMDAYNQNFIISPGLFRVVRVFRLGRLLRFFEGAKGIRKLLFTIVKSAPALSNIGTLLFLITFIYAIMGMNLFGTIAENGAITQTTNFKTFGASMCVLFRISTAAGWNAVLEGAMVQ-PPSCDPN-------MQGNCGNKLIAIIFFVTYIMVIVLIIINMYIAVILENFNQAQSQDEAGITEDDLEAYYATWEEFDPKATQFIKYSQLSDFIDALDGPLKVPKPNYWFLEQTDIPIKERYRCHCLDIMTALIKRALGDESCEESEDLSIILKKVEDRYKKLFPLRTKENDVETTRERLKTENAAAKSIQRVFRRHLLMDEINLISN 1062
            +  L+  I  S+GALGN+T++L +I++IF+V+GMQ+FG  Y +   K  +    E PR++  +F +SF+++FR+LCG+WIE  WD +++        +F+ V VIG  VVLNLFLALLLSSF+  N  + ++D E       + R+QK I++ K KIR+   KA        DE K L D         N  D  I +      GKD   + D NG         S I ++++  + +    +S + N +      I+ G+     ++    S   D+E           S G   +     E     V+ E  ++ E  + +DC+  F     CC  S +E    + W N R     ++EH +FE  I+F+I  SS  L FED+Y+ +++ +K  L Y +  F  IF LE L+K  A GF  YFTN W  LD  IV +SL SL  ++ G      +K+LR+LR LRPLRA+SRFEGM+VVVNAL+ +IPSI NVLLVC+ FWLIFSIMG NLF GKF  C++    ++ ++S VNN ++C   I       WKN  +NFD+   G+L+L Q AT +GW + M  A D+RN++ QP Y  + +  +YFV+FI+ G+FF LNLFIGVIIDNFN+ K+++     G   F+T  Q+ + N +K    KKP + + RP +K++G +FDF+  + F+  IM +I LNM++MM++  +Q +E+   L ++N VF  +FT E +L+L ++R  YF  G N+FDF++V+ SI  + +    + + +SP LFRV+R+ R+GR+LR  +GAKGIR LLF ++ S PAL NIG LLFL+ FIYAI GM+ F  +     I    NF+TFG SM  LF+I+T+AGW+ +L   +   PP CDP+       ++G+CGN  + I FFV+YI++  L+++NMYIAVILENF+ A  +    ++EDD E +Y  WE+FDP ATQFI++++LSDF DALD PL + KPN   L   D+P+    R HCLDI+ A  KR LG     ES ++  +  ++E+R+    P +     + TT +R K E  +A  IQR +RR+LL  ++  +S+
Sbjct:  867 LNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKISN--DCELPRWHMHDFFHSFLIVFRVLCGEWIETMWDCMEVAGQTMCLTVFMMVMVIGNLVVLNLFLALLLSSFSSDNLAATDDDNEMNNLQIAVGRMQKGIDFVKRKIREFIQKAFVRKQKALDEIKPLED-------LNNKKDSCISNHTTIEIGKDLNYLKDGNGT-------TSGIGSSVEKYVVDESDYMSFINNPSLTVTVPIAVGESDFENLNTEEFSSESDMEESKEKLNATSSSEGSTVDIGAPAEGEQPEVEPEESLEPEACFTEDCVRKF----KCCQIS-IEEGKGKLWWNLRKTCYKIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILEMLLKWVAYGFQVYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCINYTTGEMFDVSVVNNYSECKALIESNQTARWKNVKVNFDNVGLGYLSLLQVATFKGWMDIMYAAVDSRNVELQPKYEDNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKF----GGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPANKFQGMVFDFVTKQVFDISIMILICLNMVTMMVETDDQSQEMTNILYWINLVFIVLFTGECVLKLISLRYYYFTIGWNIFDFVVVILSIVGMFLAELIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKREVGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSGPPDCDPDKDHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSEDDFEMFYEVWEKFDPDATQFIEFAKLSDFADALDPPLLIAKPNKVQLIAMDLPMVSGDRIHCLDILFAFTKRVLG-----ESGEMDALRIQMEERFMASNPSKVSYEPITTTLKR-KQEEVSAIIIQRAYRRYLLKQKVKKVSS 1930

The following BLAST results are available for this feature:

BLAST of voltage-gated sodium channel Nav2.5 vs. Swiss-Prot (Human)

BLAST of voltage-gated sodium channel Nav2.5 vs. Swiss-Prot (Human)
Analysis Date: 2018-01-31 (Blastp Clytia hemisphaerica v1.0 proteins vs SwissProt (Homo sapiens))
Total hits: 1


Match Name	E-value	Identity	Description
SCN2A	0.000e+0	40.18	Sodium channel protein type 2 subunit alpha OS=Hom...	[more]

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voltage-gated sodium channel Nav2.5 (polypeptide) - C. hemisphaerica