TCONS_00054236-protein (polypeptide) - C. hemisphaerica

Overview


Name	TCONS_00054236-protein
Unique Name	TCONS_00054236-protein
Type	polypeptide
Organism	Clytia hemisphaerica (Jellyfish)
Sequence length	1222

Sequence

The following sequences are available for this feature:

polypeptide sequence

polypeptide sequence

>TCONS_00054236-protein ID=TCONS_00054236-protein|Name=TCONS_00054236-protein|organism=Clytia hemisphaerica|type=polypeptide|length=1222bp
MSDNTSQSSSKSKGVLTSALRKVQKQVQPTLTVQIEALTYLEDLLLQLLQ
QICSIEPHTIGDVETYLNNKFPAQIREWAINTARSAVEKKKKKTVTLPVD
KLLLTMQKEYLGYKIEPQLGMYIVAVVEYISADILKLAGNYVKNIRSDQI
TALHIKIAMHADPVILTIFNNEPELHIPLVQPSPKRGSLSYTDVLKDFIL
SEGQYIRDLNLIYKVFQQPMLERSDLFSEDDIETLFGGLSDIYETTIQFY
SMIENAFDVTEEGKEPLIGDCFEEMVEAAEFDTYEMYAECQLEEHEEGTR
GKIYELLEKSEICDFFREKGLLDVVRYVLPKLLYGPIYHFADYYEYVQLL
LQLTPDKDVDRKMLDQSLDALRHIYMKMERIISQPPLKRSVEDKVFFQQG
LGTAIPNATAKIVSIQENIEGWMGKHISQISSLFLREGMLSKPAQDGKKE
TERKAFLFDNLLVLTKQNQHTITGFGRVEYRFKERINLRKAEIKNIEDTE
ETKNCFEITEFNESPVLFCCKDEEMKYDWLSILMTLQHRTTLDRMLDVIL
QEEEQSIQLKLPDPSVYIYAEEDADDNIIFEEQSEDDTGAPVIRGGTLYK
LVERLTYHKYGDPTFIRVFLTTFRSFTTPAELLDLLIKRYDIPEPAVVED
NLGSDPNQQSLTRDEMKRFKKEYMHPIQVRVLNVLRRWVDHHFYDFTRED
VLIRQLNKFLKRIEKTRAAKKWVENIQKLTNKRLEALSLGPETYTFNEPP
PPIEWHLTKDPAEFTLLKLHPLEIGRQITLMQSEIFRSIRPSELVGSVWQ
KNDKEKLSPNALKMMRLSNLLTYWYETNLCEAQNFEERLAIYNRIIDLLM
VFIELNNFNGISEIIGFLDSSPVHRMKIIKEEFQKKSPARHQAIEYVKGF
FDRQYIKYNEKLRSINPPCIPFLGVYLRNILLSEEGNPDFLTNTDNLINF
SKRRMVAEAIGDIQKYQNMPYNLAVDEDIRNFLENLDPFQGRETNDMNNY
LFERSLEVEPRHAKKLPAFPRTSDIPLKSPGIKAGQSKYGTHGKKQSQSV
TSQISVEVPATPLPSDLEKFDLKEIEDEAPDVFFKDQPQDEEPPPLPPPL
LLPRQQPAPAPKNNSPTPAPLKKRTSRKQIIAPIEEEDLEALNRINELPS
TPAPTLPPRQRLSNPNAPEIIRDRTRSAPPIPPSIPPRRPPLGPRTSEGA
PVSSISAPIRPPDLPPRKPAQR

Run BLAST on NCBI

Gene-mRNA-Prot

This polypeptide comes from the following gene feature:


Feature Name	Unique Name	Species	Type
XLOC_034212	XLOC_034212	Clytia hemisphaerica	gene

This polypeptide derives from the following transcript feature(s):


Feature Name	Unique Name	Species	Type
TCONS_00054236	TCONS_00054236	Clytia hemisphaerica	transcript

Annotated Terms

The following terms have been associated with this polypeptide:

Vocabulary: **INTERPRO**
Term	Definition
IPR001895	RASGEF_cat_dom
IPR000219	DH-domain
IPR000651	Ras-like_Gua-exchang_fac_N
IPR001849	PH_domain
IPR011993	PH_dom-like
IPR019804	Ras_G-nucl-exch_fac_CS
IPR009072	Histone-fold
IPR023578	Ras_GEF_dom

Vocabulary: **Biological Process**
Term	Definition
GO:0007264	small GTPase mediated signal transduction
GO:0035023	regulation of Rho protein signal transduction

Vocabulary: **Molecular Function**
Term	Definition
GO:0005085	guanyl-nucleotide exchange factor activity
GO:0005089	Rho guanyl-nucleotide exchange factor activity
GO:0046982	protein heterodimerization activity

GO Annotation

GO Assignments

This polypeptide is annotated with the following GO terms.

Category	Term Accession	Term Name
biological_process	GO:0035023	regulation of Rho protein signal transduction
biological_process	GO:0007264	small GTPase mediated signal transduction
molecular_function	GO:0005085	guanyl-nucleotide exchange factor activity
molecular_function	GO:0046982	protein heterodimerization activity
molecular_function	GO:0005089	Rho guanyl-nucleotide exchange factor activity

InterPro

Analysis Name: InterPro Annotations of C. hemisphaerica v1.0
Date Performed: 2017-06-01


IPR Term	IPR Description	Source	Source Term	Source Description	Alignment
IPR001895	Ras guanine-nucleotide exchange factors catalytic domain	SMART	SM00147	RasGEF_3	coord: 766..1012 e-value: 2.2E-64 score: 229.9
IPR001895	Ras guanine-nucleotide exchange factors catalytic domain	PFAM	PF00617	RasGEF	coord: 773..954 e-value: 3.4E-38 score: 131.5
IPR001895	Ras guanine-nucleotide exchange factors catalytic domain	GENE3D	1.10.840.10		coord: 751..1035 e-value: 1.1E-63 score: 214.7
IPR001895	Ras guanine-nucleotide exchange factors catalytic domain	PROSITE	PS50009	RASGEF_CAT	coord: 770..1011 score: 53.69
IPR001895	Ras guanine-nucleotide exchange factors catalytic domain	CDD	cd00155	RasGEF	coord: 766..1007 e-value: 2.35386E-55 score: 192.853
IPR000219	Dbl homology (DH) domain	SMART	SM00325	RhoGEF_3	coord: 194..380 e-value: 4.5E-17 score: 72.7
IPR000219	Dbl homology (DH) domain	PFAM	PF00621	RhoGEF	coord: 194..377 e-value: 1.5E-15 score: 57.8
IPR000219	Dbl homology (DH) domain	PROSITE	PS50010	DH_2	coord: 190..381 score: 20.403
IPR000219	Dbl homology (DH) domain	SUPERFAMILY	48065	DBL homology domain (DH-domain)	coord: 191..382
IPR000651	Ras-like guanine nucleotide exchange factor, N-terminal	SMART	SM00229	rasgefn_5	coord: 588..734 e-value: 4.9E-35 score: 132.4
IPR000651	Ras-like guanine nucleotide exchange factor, N-terminal	PFAM	PF00618	RasGEF_N	coord: 593..709 e-value: 7.8E-30 score: 103.1
IPR000651	Ras-like guanine nucleotide exchange factor, N-terminal	PROSITE	PS50212	RASGEF_NTER	coord: 589..734 score: 31.195
IPR000651	Ras-like guanine nucleotide exchange factor, N-terminal	CDD	cd06224	REM	coord: 597..732 e-value: 1.85393E-30 score: 117.128
IPR001849	Pleckstrin homology domain	SMART	SM00233	PH_update	coord: 434..540 e-value: 2.7E-11 score: 53.5
IPR001849	Pleckstrin homology domain	PFAM	PF00169	PH	coord: 435..532 e-value: 4.1E-9 score: 36.8
IPR001849	Pleckstrin homology domain	PROSITE	PS50003	PH_DOMAIN	coord: 433..538 score: 12.189
IPR011993	PH domain-like	GENE3D	2.30.29.30		coord: 413..543 e-value: 1.4E-19 score: 69.5
IPR011993	PH domain-like	SUPERFAMILY	50729	PH domain-like	coord: 410..564
None	No IPR available	GENE3D	1.20.870.10		coord: 560..747 e-value: 1.6E-42 score: 144.9
None	No IPR available	GENE3D	1.10.20.10		coord: 8..162 e-value: 5.5E-15 score: 55.3
None	No IPR available	GENE3D	1.20.900.10		coord: 186..393 e-value: 4.9E-25 score: 87.8
None	No IPR available	MOBIDB_LITE	mobidb-lite	disorder_prediction	coord: 1015..1065
None	No IPR available	MOBIDB_LITE	mobidb-lite	disorder_prediction	coord: 1084..1222
None	No IPR available	CDD	cd00160	RhoGEF	coord: 191..374 e-value: 3.34053E-24 score: 100.835
IPR019804	Ras guanine-nucleotide exchange factor, conserved site	PROSITE	PS00720	RASGEF	coord: 920..952
IPR009072	Histone-fold	SUPERFAMILY	47113	Histone-fold	coord: 5..169
IPR023578	Ras guanine nucleotide exchange factor domain	SUPERFAMILY	48366	Ras GEF	coord: 560..1023

Blast

[Close]

BLAST of TCONS_00054236-protein vs. Swiss-Prot (Human)
Match: SOS1 (Son of sevenless homolog 1 OS=Homo sapiens GN=SOS1 PE=1 SV=1)

HSP 1 Score: 884.019 bits (2283), Expect = 0.000e+0
Identity = 472/1057 (44.65%), Postives = 687/1057 (65.00%), Query Frame = 0

Query:    5 TSQSSSKSKGVLTSALRKVQKQVQPTLTVQIEALTYLEDLLLQLLQQICSIEPHTIGDVETYLNNKFPAQIREWAINTARSAVEKKKKKT-VTLPVDKLLLTMQKEYLGYKIEPQLGMYIVAVVEYISADILKLAGNYVKNIRSDQITALHIKIAMHADPVILTIFNNEPE----LHIPLVQPSPKRGSLSYTDVLKDFILSEGQYIRDLNLIYKVFQQPMLERSDLFSEDDIETLFGGLSDIYETTIQFYSMIENAFDVTEEGK-EPLIGDCFEEMVEAAEFDTYEMYAECQLEEHEEGTRGKIYELLEKSEICDFFRE--KGLLDVVRYVLPKLLYGPIYHFADYYEYVQLLLQLTPDKDVDRKMLDQSLDALRHIYMKMERIISQPPLKRSVED---KVFFQQGLGTAIPNATAKIVSIQENIEGWMGKHISQISSLFLREGMLSKPAQDGKKETERKAFLFDNLLVLTKQN--QHTITGFGRVEYRFKERINLRKAEIKNIEDTEETKNCFEITEFNESPVLFCCKDEEMKYDWLSILMTLQHRTTLDRMLDVILQEEEQSIQLKLPDPSVYIYAEEDADDNIIFEEQSEDDTGAPVIRGGTLYKLVERLTYHKYGDPTFIRVFLTTFRSFTTPAELLDLLIKRYDIPEPAVVE-DNLGSDPNQQSLTRDEMKRFKKEYMHPIQVRVLNVLRRWVDHHFYDFTREDVLIRQLNKFLKRIEKTRAAKKWVENIQKLTNKRLEALSLGP-ETYTFNEPPPPIEWHLTKDPAE---FTLLKLHPLEIGRQITLMQSEIFRSIRPSELVGSVWQKNDKEKLSPNALKMMRLSNLLTYWYETNLCEAQNFEERLAIYNRIIDLLMVFIELNNFNGISEIIGFLDSSPVHRMKIIKEEFQKKSPARHQAI-EYVKGFFDRQYIKYNEKLRSINPPCIPFLGVYLRNILLSEEGNPDFLT-NTDNLINFSKRRMVAEAIGDIQKYQNMPYNLAVDEDIRNFLENLDPFQGRETNDMNNYLFERSLEVEPRHAKKLPAFPRTSDIPLKSPGIKAGQSKYGT 1041
            + +++ K +G+L  AL+KVQ QV PTL    +AL Y+E+L+LQLL  +C  +P +  DVE  +   FP  I +WAI  A+SA+EK+K++  ++LPV+K+   + KE LGYKI+ Q+ +YIVAV+EYISADILKL GNYV+NIR  +IT   IK+AM AD V++ +F+ + E    L +   +PS   G  +Y D++K F+    QYIR+LNLI KVF++P +  S LFS +D+E +F  + DI+E +++    IE+  ++T+EG   PL+G CFE++ E   FD YE YA   L     G   +    L K     + +   +G  + V+YVLP+LL  P+YH   Y+E ++ L + + D++ D++ L Q++ AL ++   ME+I S+   KR + +   + + QQ  G  +  A  K+  IQ+NI+GW GK I Q  + F+ EG L++    G K  ER  FLFD L++  K N  Q  + G    EYR KE+  +RK +I + +DT E K+ FEI   +E+ V+F  K  E K +W++ L++LQ+R+TL+RMLDV + +EE+  Q++LP   VY +AE D+++NIIFEE  +   G P+I+ GT+ KL+ERLTYH Y DP F+R FLTT+RSF  P ELL L+I+R++IPEP   E D +  +   Q L+  E+KRF+KEY+ P+Q+RVLNV R WV+HHFYDF R+  L++++ +F+  + + +A KKWVE+I K+  ++  A   GP    TF   PP +EWH+++ P     F LL LHP+EI RQ+TL++S+++R+++PSELVGSVW K DKE  SPN LKM+R +  LT W+E  + E +N EER+A+ +RII++L VF ELNNFNG+ E++  ++SSPV+R+    E+     P+R + I E      +  Y KY  KLRSINPPC+PF G+YL NIL +EEGNP+ L  +   LINFSKRR VAE  G+IQ+YQN PY L V+ DI+ F ENL+P       +  +YLF +SLE+EPR+ K LP FP+    PLKSPG++    + GT
Sbjct:   12 SEENAPKWRGLLVPALKKVQGQVHPTLESNDDALQYVEELILQLLNMLCQAQPRSASDVEERVQKSFPHPIDKWAIADAQSAIEKRKRRNPLSLPVEKIH-PLLKEVLGYKIDHQVSVYIVAVLEYISADILKLVGNYVRNIRHYEITKQDIKVAMCADKVLMDMFHQDVEDINILSLTDEEPS-TSGEQTYYDLVKAFMAEIRQYIRELNLIIKVFREPFVSNSKLFSANDVENIFSRIVDIHELSVKLLGHIEDTVEMTDEGSPHPLVGSCFEDLAEELAFDPYESYARDILRP---GFHDRFLSQLSKPGAALYLQSIGEGFKEAVQYVLPRLLLAPVYHCLHYFELLKQLEEKSEDQE-DKECLKQAITALLNVQSGMEKICSKSLAKRRLSESACRFYSQQMKGKQL--AIKKMNEIQKNIDGWEGKDIGQCCNEFIMEGTLTRV---GAKH-ERHIFLFDGLMICCKSNHGQPRLPGASNAEYRLKEKFFMRKVQINDKDDTNEYKHAFEIILKDENSVIFSAKSAEEKNNWMAALISLQYRSTLERMLDVTMLQEEKEEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSA-ELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTV-RGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISR-PGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQI----PSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT 1049

The following BLAST results are available for this feature:

BLAST of TCONS_00054236-protein vs. Swiss-Prot (Human)

BLAST of TCONS_00054236-protein vs. Swiss-Prot (Human)
Analysis Date: 2018-01-31 (Blastp Clytia hemisphaerica v1.0 proteins vs SwissProt (Homo sapiens))
Total hits: 1


Match Name	E-value	Identity	Description
SOS1	0.000e+0	44.65	Son of sevenless homolog 1 OS=Homo sapiens GN=SOS1...	[more]

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TCONS_00054236-protein (polypeptide) - C. hemisphaerica