Sequence
The following sequences are available for this feature:
polypeptide sequence
>TCONS_00065116-protein ID=TCONS_00065116-protein|Name=TCONS_00065116-protein|organism=Clytia hemisphaerica|type=polypeptide|length=962bp DYPYEPSLNLQRKFQPPSSSVNQNNTYEQADPAAMRDFVSAMETKKQQQN GQVSYDSQHSSDDNYDLPPDDLYQDPETANFNQAPPPIPRHLSTTQNKDS DSDSDIYDEPPDELYQDPESVNFHKAPIPKPPKNNNNNDNKKNNKKKGLF NFNKKTKPTKQPSIDDMDDGAYQDPDEASFHTQPPSTSAAQQKPSYSTCQ STDDDMDDLYQDPEEIDFNTAALLNSKNTKPQLQRCDSNYDSPLEDYDEP PLDARCPVAPSHRNQNAADSSDDDDVYDFPDSEPPQIPNHKKSSEIPPVI PHHKKSSGIPPAIPIHKKSTSQEPDHSENNLHSSSSDEDDSLDYNDPETF FAKPPALTNLKNGGRLASLRRGSNALQPLEYMPASEFTSSMDDADDDLYC DPETSLTVKPPSFYGRNSDGEEIYSDEPLYQVYNKEVINAAHRESKKKDD EVAINHLKQLTEDLMHKGSTMRILWSELPSVRNSGFLDNISPDDRKRQEA MFEVITSEASYLKSLDILISHFMLNRDLLPNPNHPSHEGDELPQLLDRQQ YHFLFSGLSAIKGVSERFLKDLRKRQQSSILMDSISDILLDYASNHLTCY VKYCSNQVFQDRTFQHLLDTSPAFVNKLSELEKDPITQGLSLQSFLTLPM QRITRLPLLVDAICRRCTPASEEFEKTDTALKALNAVVKESNEGARQMVR TEEMYFIQKNLIWKTKPIPLISTSRWLVKKGDLMCLHEEGRFSQFKNQLR QIFKGKFKPIYIFLFTDIVLVTKMKGEDKYKVIDVCQRSSLRCEIMKNIP DPEPPKMGTLATMNVNPLKYAFTLILLENANGKTVDYHFFLSTETDKTRW MEALSPPKSNTPTVEGESIYEEWDCPQVQAIHQYVAQQPDELTLMEGDVI SVLRKLPDGWAEGMLLRDDTRGWFPINHTDEIDSRHMRAKNLMQRYRLIT ASKNVINEILGK Run BLAST on NCBI
Gene-mRNA-Prot
This polypeptide comes from the following
gene feature:
This polypeptide derives from the following
transcript feature(s):
Annotated Terms
The following terms have been associated with this polypeptide:
Vocabulary: Molecular Function
Term Definition
GO:0005515 protein binding
GO:0005089 Rho guanyl-nucleotide exchange factor activity
Vocabulary: Biological Process
Term Definition
GO:0035023 regulation of Rho protein signal transduction
GO Annotation
GO Assignments
This polypeptide is annotated with the following GO terms.
Category
Term Accession
Term Name
biological_process
GO:0035023
regulation of Rho protein signal transduction
molecular_function
GO:0005515
protein binding
molecular_function
GO:0005089
Rho guanyl-nucleotide exchange factor activity
InterPro
Analysis Name:
InterPro Annotations of C. hemisphaerica v1.0
Date Performed: 2017-06-01
100 200 300 400 500 600 700 800 900 Expect = 4.6E-18 / Score = 76.0 Expect = 1.4E-12 / Score = 46.9 Score = 13.63 Score = Expect = 3.2E-34 / Score = 129.7 Expect = 3.8E-32 / Score = 111.9 Score = 28.844 Score = Expect = 3.6E-4 / Score = 29.8 Expect = 2.5E-15 / Score = 55.9 Score = Expect = 3.1E-9 / Score = 35.7 Expect = 1.5E-43 / Score = 148.3 Expect = 1.5E-11 / Score = 43.2 Score = Expect = 2.70859E-27 / Score = 109.31 Expect = 1.31571E-37 / Score = 137.387 Expect = 1.56749E-27 / Score = 106.266 Sequence SM00326 PF00018 PS50002 SSF50044 SM00325 PF00621 PS50010 SSF48065 SM00233 G3DSA:2.30.29.30 SSF50729 G3DSA:2.30.30.40 G3DSA:1.20.900.10 G3DSA:2.30.30.40 mobidb-lite cd00160 cd01221 cd11793
IPR Term IPR Description Source Source Term Source Description Alignment
IPR001452 SH3 domain SMART SM00326 SH3_2 coord: 876..933 e-value: 4.6E-18 score: 76.0
IPR001452 SH3 domain PFAM PF00018 SH3_1 coord: 879..925 e-value: 1.4E-12 score: 46.9
IPR001452 SH3 domain PROSITE PS50002 SH3 coord: 878..934 score: 13.63
IPR001452 SH3 domain SUPERFAMILY 50044 SH3-domain coord: 873..938
IPR000219 Dbl homology (DH) domain SMART SM00325 RhoGEF_3 coord: 500..693 e-value: 3.2E-34 score: 129.7
IPR000219 Dbl homology (DH) domain PFAM PF00621 RhoGEF coord: 501..692 e-value: 3.8E-32 score: 111.9
IPR000219 Dbl homology (DH) domain PROSITE PS50010 DH_2 coord: 496..694 score: 28.844
IPR000219 Dbl homology (DH) domain SUPERFAMILY 48065 DBL homology domain (DH-domain) coord: 478..711
IPR001849 Pleckstrin homology domain SMART SM00233 PH_update coord: 727..861 e-value: 3.6E-4 score: 29.8
IPR011993 PH domain-like GENE3D 2.30.29.30 coord: 718..863 e-value: 2.5E-15 score: 55.9
IPR011993 PH domain-like SUPERFAMILY 50729 PH domain-like coord: 702..859
None No IPR available GENE3D 2.30.30.40 coord: 864..901 e-value: 3.1E-9 score: 35.7
None No IPR available GENE3D 1.20.900.10 coord: 494..717 e-value: 1.5E-43 score: 148.3
None No IPR available GENE3D 2.30.30.40 coord: 902..949 e-value: 1.5E-11 score: 43.2
None No IPR available MOBIDB_LITE mobidb-lite disorder_prediction coord: 1..357
None No IPR available CDD cd00160 RhoGEF coord: 497..692 e-value: 2.70859E-27 score: 109.31
None No IPR available CDD cd01221 PH_ephexin coord: 714..861 e-value: 1.31571E-37 score: 137.387
None No IPR available CDD cd11793 SH3_ephexin1_like coord: 877..931 e-value: 1.56749E-27 score: 106.266
Blast
BLAST of TCONS_00065116-protein vs. Swiss-Prot (Human)
Match:
NGEF (Ephexin-1 OS=Homo sapiens GN=NGEF PE=1 SV=2)
HSP 1 Score: 343.969 bits (881), Expect = 1.632e-105
Identity = 194/475 (40.84%), Postives = 278/475 (58.53%), Query Frame = 0
Query: 474 LWSELPSVRNSGFLDNISPDDRKRQEAMFEVITSEASYLKSLDILISHFMLNRDLLPNPNHPSHEGDELPQLLDRQQYHFLFSGLSAIKGVSERFLKDLRKRQQSSILMDSISDILLDYASNHLTCYVKYCSNQVFQDRTFQHLLDTSPAFVNKLSELEKDPITQGLSLQSFLTLPMQRITRLPLLVDAICRRCTPASEEFEKTDTALKALNAVVKESNEGARQMVRTEEMYFIQKNLIWKTKPIPLISTSRWLVKKGDLMCLHEEGRFSQFKNQLRQIFKGKFKPIYIFLFTDIVLVTKMKGEDKYKVIDVCQRSSLRCEIMKNIPDPEPPKMGTLATMNVNPLKYAFTLILLENANGKTVDYHFFLSTETDKTRWMEALSPPKSNTPTVEGESIYEEWDCPQVQAIHQYVAQQPDELTLMEGDVISVLRKLPDGWAEGMLLRDDTRGWFPINHTDEIDSRHMRAKNLMQRYRL 948
LW +LP +R+SG L+ + P++ K QEAMFE++TSEASY KSL++L+SHFM E + + ++L + H LFS + + VSERFL +L R + +I++ + DI+ YA++H + Y+ Y SNQ +Q+RT++ LL AF +++LE DP +GL SFL LP QRITRL LLV I +R SE A K L VVK NEG R+M RTE+M IQK + +K K +P+IS SRWL+K+G+L + S K K F IY+FLF D++++ + DKY+V D R LR E +++ + TLA + F L LLENA+ + Y S++++ RWM +L+P + T V S DCPQVQ +H YVAQQPDELTL D++++L K DGW G L D RGWFP + T+EI + +R++NL + +R+
Sbjct: 251 LWQDLPEIRSSGVLEILQPEEIKLQEAMFELVTSEASYYKSLNLLVSHFM--------------ENERIRKILHPSEAHILFSNVLDVLAVSERFLLELEHRMEENIVISDVCDIVYRYAADHFSVYITYVSNQTYQERTYKQLLQEKAAFRELIAQLELDPKCRGLPFSSFLILPFQRITRLKLLVQNILKRVEERSERECTALDAHKELEMVVKACNEGVRKMSRTEQMISIQKKMEFKIKSVPIISHSRWLLKQGELQ------QMSGPKTSRTLRTKKLFHEIYLFLFNDLLVICRQIPGDKYQVFDSAPRGLLRVEELED-------QGQTLANV--------FILRLLENADDREATYMLKASSQSEMKRWMTSLAPNR-RTKFVSFTSRL--LDCPQVQCVHPYVAQQPDELTLELADILNILDKTDDGWIFGERLHDQERGWFPSSMTEEILNPKIRSQNLKECFRV 687
The following BLAST results are available for this feature: