voltage-gated sodium channel Nav2.1 (polypeptide) - C. hemisphaerica

BLAST of voltage-gated sodium channel Nav2.1 vs. Swiss-Prot (Human)
Match: SCNAA (Sodium channel protein type 10 subunit alpha OS=Homo sapiens GN=SCN10A PE=1 SV=2)

HSP 1 Score: 1076.62 bits (2783), Expect = 0.000e+0
Identity = 663/1860 (35.65%), Postives = 1024/1860 (55.05%), Query Frame = 0

Query:  142 LIGSKRRRTRP---SDETFLVLASRLGKVYVYRFSKAKSLWAFGPTNPIRKIIIYLITNQIFEFFVILTILVNCVFLALNDAPEEAEYFFTAIYTTEMVLKIIAKGFVLHNFAYLRDPWNWLDFVVVLLGYVTLAPTITVNFHGIRTFRVLRALRTISAIEGLKTMVNALLKSMRMLSDVLILTAFFLCVFALVGLQLFSGQFHNRCVHNNFTISPYNTSWSSHVSNETNWYKEFT----ICGNNTGSRQCPTNYTCLPHAGPNPNYGFTSYDDFGWALLTSFQLVTLDYWEDVYLHIASSMGPWYVLYFMIVIFFGSFYLINLVLAVVAVSYQQETAQNAD-LESQYEFLREVAASYSLHKRILPKLLFDDSTIDDISNLPCVKKGPSVIILSSTKNNKSKRAANKSIAFGRCFHVSKRTVSESSNADSEEPQ-NPQQQEESSAIARKKLTNVINRVKMDRERDKLKD---ERNKTEDVAVVGEHGRRKLNIASVKSVGRTLYVPTTPGREGEELDSSRDSKNLNSSNTS--AQNTFSLNGKTALHQKRNKTENALN--------TSGASHVTFNEQLTNQTHSTKPTSTSAARNARLARNMAQIEHPLPYANIEENDLTCLQLTRRKVYRFVMSPWFELAVTIFILLNTVCLAIEHHNMDKNIEFVLQIANHVFTGIFILEMVLKLIALGLIGYTKSMWNIFDGLVVLMSIVDVIIEITIARDNGDFTIIRSLRLFRVLKLAQSWSTMRLLLSAIGRSLNALGNLTLILGIIVYMFAVVGTKVFGASYVAEK----FPENKVPHWNFSNFGHSIMMIFRVLCGEWIEPLYHCM-LATGTWAAAFFMLALIVGNFLVLNLFLALLLNSFADQAM-----EEELKKRSFIKSKLKWVSSTRKLAKLQKAFKGQKVFPNGEMSLAAASKLALAKKREE--------EAKNGGGCPSKPALEKKTSF--EITAKTSPRNAEGHSDSECPQHQNNENTNNTNKTAKSNNNTLTIANF----NELT--SPTNGSIS-------GRHMALSPTPSIFSNHSKLNGTTASIASSVALHKLDPLCPKTYCCCFGRKNQNSTTTPGGQQKRPSSSALPGKSEWKMVWMRFQGKVKKLVEHKWFDSFILLLILSSSFVLVFEDIRLPERPQLQTALDILNIVFSVLFLIECILKIIGFGVAGYIKNPWNLLDFIIVSISITSIVLDKSSDSDSGNLKTLRSLRTLRALRPLRAVSRWDGMRIVVNSLLKAIPSIGNVLLVCLVFWLIFSILGVQIFGGRFYKCV---DGDGNILDYRIIPNRTEC---DRHPQYYWKNSNVNFDNSLNGFLPLFQVATFEGWIEVMKDAIDATEVDKQPIPGNNFSAYIYFVIFIIVGAFFILNLFISVIIDNFYRLKKQYDDCGTVEVFLTTEQKQWFSTVKKALTKKPKRIIHRPKNFYQAKLFDFIISPKFESFTMILIFVNIILMMFQHYQQSTDYDRMLYVTNLVFTVIFSIELILRIVALRQQYFLDRWNIFDLGIVILSLIGIVLEYLDVVLQ--VTPSVLRVARVLRIGRLLRYFNSAKGIRRLLVALVISLPALFNIGALLFLILFIYAIIGMSNFGYVKKNGALNEVVNFETFGSSMMVLFRLATSAGWNEVLDALM-ISEPDCDPNLNSVPN-----GNCGTPWIAVAYFVTFILITYLIIVNMYIAVILENFNQAHEQEEIGITDEDIEMFYAVWQLYDPLATQFIDYEKLPFLVANLGPPLGIPFPNKVAVHNLDLPMNDSDEIHCIDVLQALLKRVLGNIENTDTEHYDNMRKTIDMKLQAAFPMRQKEDHKTTTMERLQQVKAASTIQRHFRSW 1932
            LIG       P   +  TF+VL    G+  + RFS  ++LW F P N IR+  I +  +  F  F+ +TILVNCV +   D PE+ EY FT IYT E ++KI+A+GF L+ F YLRDPWNWLDF V+ L YV  A  +     G+RTFRVLRAL+T+S I GLK +V AL+ S++ L+DV ILT F L VFALVGLQLF G   N+CV N+  ++   T++SSH   +    K  T    +CGN + S  CP  Y CL     NP++ +TS+D F WA L+ F+L+T D WE +Y     + G  Y+++F++VIF GSFYL+NL+LAVV ++Y+++     D +E++ +  +E        + +L  L  D +++   +  P            ++KN   +R            H  K  VSE S  D++ P+ +P  Q   S +         +   +   R   +D       T+D    G+H   + ++      G+   +P +P  +    DS           TS  A     ++   A  +K   +   L+         S  S +T   +   ++    P   ++     L  +   +   L                +  ++  V  P+ EL +T+ I++NT+ +A+EHH M    E +LQI N VFT  F  EMV K+IA     Y +  WNIFD ++V +S+    +E+ +A+  G  +++RS RL RV KLA+SW T+  L+  IG S+ ALGNLT+IL IIV++FA+VG ++ G +Y   +     P    P W+  +F HS +++FR+LCGEWIE ++ CM +   +     F+  +++GN +VLNLF+ALLLNSF+   +     + E+       ++++ V   R    L   F     FP  +       KL L+  + E           +GG    +   ++ + F    T   S   AEG SD +  +    E+  +  +          +       + LT  SP  G+ S       G        P + +    ++ T++S  S+V     + +  K        +  +   T G  +  P       KS W + W + +    ++VEH WF+SFI+ +IL SS  L FED  L ++P ++  L+  + VF+ +F+ E +LK + +G   Y  N W  LDF+IV+IS+ S+       S+   +K   +LRTLRALRPLRA+SR++GMR+VV++L+ AIPSI NVLLVCL+FWLIFSI+GV +F G+F++C+   DG+ +++   I+ N+++C   +    ++W N  VNFDN   G+L L QVATF+GW+++M  A+D+ EV+ QP   +N   Y+YFVIFII G FF LNLF+ VIIDNF + KK+    G  ++F+T EQK++++ +KK  +KKP++ I RP N +Q  +FD +    F+   M+LI +N+I MM +   QS +  ++L   N  F  +F+ E ++++ ALRQ YF + WN+FD  +V+LS+  ++   +   LQ   +P++ RV R+ RIGR+LR   +AKGIR LL AL++SLPALFNIG LLFL++FIY+I GMS+F +V+    ++++ NF+TF +SM+ LF++ TSAGW+ +L  ++    P CDPNL   PN     G+CG+P + + +F T+I+I++LI+VNMYIAVILENFN A E+    ++++D +MFY  W+ +DP ATQFI +  L      L  PL IP PN+  +  +DLP+   D+IHC+D+L A  K VLG     ++   D+++  ++ K  A    +   +   TT+   Q+  +A+ IQ+ +RS+
Sbjct:   74 LIGEPLEDLDPFYSTHRTFMVLNK--GRT-ISRFSATRALWLFSPFNLIRRTAIKVSVHSWFSLFITVTILVNCVCMTRTDLPEKIEYVFTVIYTFEALIKILARGFCLNEFTYLRDPWNWLDFSVITLAYVGTAIDLR-GISGLRTFRVLRALKTVSVIPGLKVIVGALIHSVKKLADVTILTIFCLSVFALVGLQLFKGNLKNKCVKNDMAVNE-TTNYSSHRKPDIYINKRGTSDPLLCGNGSDSGHCPDGYICL-KTSDNPDFNYTSFDSFAWAFLSLFRLMTQDSWERLYQQTLRTSGKIYMIFFVLVIFLGSFYLVNLILAVVTMAYEEQNQATTDEIEAKEKKFQEALEMLRKEQEVLAALGIDTTSLHSHNGSPL-----------TSKNASERR------------HRIKPRVSEGSTEDNKSPRSDPYNQRRMSFLGLASGKRRASHGSVFHFRSPGRDISLPEGVTDDGVFPGDHESHRGSLLLGGGAGQQGPLPRSPLPQPSNPDSRHGEDEHQPPPTSELAPGAVDVSAFDAGQKKTFLSAEYLDEPFRAQRAMSVVSIITSVLEELEESEQKCPPCLTSLSQKYLIWDCCPMWVKL----------------KTILFGLVTDPFAELTITLCIVVNTIFMAMEHHGMSPTFEAMLQIGNIVFTIFFTAEMVFKIIAFDPYYYFQKKWNIFDCIIVTVSL----LELGVAK-KGSLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTIILAIIVFVFALVGKQLLGENYRNNRKNISAPHEDWPRWHMHDFFHSFLIVFRILCGEWIENMWACMEVGQKSICLILFLTVMVLGNLVVLNLFIALLLNSFSADNLTAPEDDGEVNNLQVALARIQ-VFGHRTKQALCSFFSRSCPFPQPKAEPELVVKLPLSSSKAENHIAANTARGSSGGLQAPRGPRDEHSDFIANPTVWVSVPIAEGESDLDDLEDDGGEDAQSFQQEVIPKGQQEQLQQVERCGDHLTPRSPGTGTSSEDLAPSLGETWKDESVPQVPAE--GVDDTSSSEGSTVDCLDPEEILRKIPELADDLEEPDDCFTEGCIRHCPCCKLDTTKSPWDVGW-QVRKTCYRIVEHSWFESFIIFMILLSSGSLAFEDYYLDQKPTVKALLEYTDRVFTFIFVFEMLLKWVAYGFKKYFTNAWCWLDFLIVNISLISLTAKILEYSEVAPIK---ALRTLRALRPLRALSRFEGMRVVVDALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFWRCINYTDGEFSLVPLSIVNNKSDCKIQNSTGSFFWVNVKVNFDNVAMGYLALLQVATFKGWMDIMYAAVDSREVNMQPKWEDNVYMYLYFVIFIIFGGFFTLNLFVGVIIDNFNQQKKKL---GGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKFQGFVFDIVTRQAFDITIMVLICLNMITMMVETDDQSEEKTKILGKINQFFVAVFTGECVMKMFALRQYYFTNGWNVFDFIVVVLSIASLIFSAILKSLQSYFSPTLFRVIRLARIGRILRLIRAAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMSSFPHVRWEAGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPNL---PNSNGTRGDCGSPAVGIIFFTTYIIISFLIMVNMYIAVILENFNVATEESTEPLSEDDFDMFYETWEKFDPEATQFITFSALSDFADTLSGPLRIPKPNRNILIQMDLPLVPGDKIHCLDILFAFTKNVLG-----ESGELDSLKANMEEKFMATNLSKSSYEPIATTLRWKQEDISATVIQKAYRSY 1865