TCONS_00059321-protein (polypeptide) - C. hemisphaerica

Overview


Name	TCONS_00059321-protein
Unique Name	TCONS_00059321-protein
Type	polypeptide
Organism	Clytia hemisphaerica (Jellyfish)
Sequence length	1366

Sequence

The following sequences are available for this feature:

polypeptide sequence

polypeptide sequence

>TCONS_00059321-protein ID=TCONS_00059321-protein|Name=TCONS_00059321-protein|organism=Clytia hemisphaerica|type=polypeptide|length=1366bp
MANLIEDQKISEIIQRSKLSPTFAGCLKRLTRERKWIDRYCLLYQNFLIE
FEDQCCLKATCLIPLEHYQAKRMEINNIDDIYKQNVFYLCDISQKMLMLK
QNEVYRANDETSCRDWVDAINQSSYAVLKSMKEELEYRNVHLLSVIESER
ETKWKLEEFAQEQRNQLESLRKEIPAMISKKVDEALQQNEPSTKESDDLI
KIKKIQSFFRGLICRRRWHSIVQDYIRSPHAESMRKRNCVVFQLVRSEEE
YVECLSILVSAFYRPCKMAASSKNKPLSHDEVNSIFLNSETLMFLHQIFL
KGLQTRMESWPKVVLGDLFDMLLPMLSIYQEYVRNHHYSLQTLSDCKQRS
SFRKTLKSLENSTVAGNRTLDTFLTYPMHRIPKYIAAIQKLLALTQYDHV
ERVALEHSQSVLEELSSVMHDEVSETENIRKNLCIERMFTESCDFLLNTD
EILIRQGVLLQLTMDYQNGKKLARKKSAETKTESVRHCFLFSQMFLVATR
VSGGKLQLINKGKFMLKNATLIEDIVDEDIDFINFPRASRHASLAFKLVV
SDKDESAHKLILMAASPSDKAAWTSDISQCKENLRNPSEEETVSVQSRRS
LLSIRADTTLTTDAVDIKYSRALDSCRLPRIQYATVQRLLGRLLDVRFLS
VEFLNTFLTTHSIFTTSSILMETIIEFYYARASCTGSGVKDSIRLDYDDH
SKVRALSPSNSLLPPLSLANRRHSSPSIFTDVMETNHHKTVDKTEIMKLR
TLSVGYPKHTCGDSQDAMSYPIHPTLSFSTTKSSIKSSRSSNLSSSSNFC
LSPREIESPSVSPSFKHAEPLKTNNSVINTKIIKLTSPPKNRSEMKQSRY
KPTKIGPVDLVETSMSGSKGLNIDLPKDEVVKEPKKSKIKRATEKQLLSP
NNANYLNKIFKFEPQRFDCNNNGGSGGSHGNCSGDDEIASINARVGPLSP
LRSGEFQRSPSPRSPLKTPPTPGVVVTSYRLSQKRSSITNAAIAFAAATA
GATISPAASPKSGFKFRFSLKFTDTEDGNIVTKRVLKILKHWVTKQPETI
QRNKELKNKLENFLLKLIQMDDTAPIERKLANSILKSLVAGEQSFKKNLL
NVEILPSVEASSTFDQTSTLVIAEQMTLLDHILLKEIPSKEFLGATWMKD
GKQKRAKNIMDAINQFNVTSRLVSTEILSRPTPALRASVIEKWTVVADMC
RCLHNFNSVLAIITSFTSSAIFRLKKTWEKVSKQTQILIEKLKTIVSADG
RFRNMREALKCCDPPSVPYLGFYLTDLASIEEQTSVIRESSLVNFAKMRM
ITNVIQEIRFYQSSSYMIEKNEKIMAYLMCVKHVKDEDRIYKLSLDLERK
NSHAANKLKFAFHFGQ

Run BLAST on NCBI

Gene-mRNA-Prot

This polypeptide comes from the following gene feature:


Feature Name	Unique Name	Species	Type
XLOC_037356	XLOC_037356	Clytia hemisphaerica	gene

This polypeptide derives from the following transcript feature(s):


Feature Name	Unique Name	Species	Type
TCONS_00059321	TCONS_00059321	Clytia hemisphaerica	transcript

Annotated Terms

The following terms have been associated with this polypeptide:

Vocabulary: **INTERPRO**
Term	Definition
IPR000219	DH-domain
IPR001849	PH_domain
IPR001895	RASGEF_cat_dom
IPR011993	PH_dom-like
IPR000651	Ras-like_Gua-exchang_fac_N
IPR019804	Ras_G-nucl-exch_fac_CS
IPR000048	IQ_motif_EF-hand-BS
IPR023578	Ras_GEF_dom

Vocabulary: **Biological Process**
Term	Definition
GO:0035023	regulation of Rho protein signal transduction
GO:0007264	small GTPase mediated signal transduction

Vocabulary: **Molecular Function**
Term	Definition
GO:0005089	Rho guanyl-nucleotide exchange factor activity
GO:0005085	guanyl-nucleotide exchange factor activity
GO:0005515	protein binding

GO Annotation

GO Assignments

This polypeptide is annotated with the following GO terms.

Category	Term Accession	Term Name
biological_process	GO:0035023	regulation of Rho protein signal transduction
biological_process	GO:0007264	small GTPase mediated signal transduction
molecular_function	GO:0005085	guanyl-nucleotide exchange factor activity
molecular_function	GO:0005515	protein binding
molecular_function	GO:0005089	Rho guanyl-nucleotide exchange factor activity

InterPro

Analysis Name: InterPro Annotations of C. hemisphaerica v1.0
Date Performed: 2017-06-01


IPR Term	IPR Description	Source	Source Term	Source Description	Alignment
None	No IPR available	COILS	Coil	Coil	coord: 1053..1073
None	No IPR available	COILS	Coil	Coil	coord: 153..180
None	No IPR available	GENE3D	1.20.900.10		coord: 231..441 e-value: 4.6E-46 score: 156.4
None	No IPR available	GENE3D	1.20.870.10		coord: 604..1088 e-value: 7.0E-18 score: 64.5
None	No IPR available	MOBIDB_LITE	mobidb-lite	disorder_prediction	coord: 949..972
None	No IPR available	CDD	cd00160	RhoGEF	coord: 237..417 e-value: 1.00313E-32 score: 125.873
IPR000219	Dbl homology (DH) domain	SMART	SM00325	RhoGEF_3	coord: 240..421 e-value: 3.3E-46 score: 169.5
IPR000219	Dbl homology (DH) domain	PFAM	PF00621	RhoGEF	coord: 240..417 e-value: 3.1E-29 score: 102.4
IPR000219	Dbl homology (DH) domain	PROSITE	PS50010	DH_2	coord: 236..422 score: 27.769
IPR000219	Dbl homology (DH) domain	SUPERFAMILY	48065	DBL homology domain (DH-domain)	coord: 217..438
IPR001849	Pleckstrin homology domain	SMART	SM00233	PH_update	coord: 21..127 e-value: 1.1E-5 score: 34.9 coord: 453..584 e-value: 8.1E-6 score: 35.3
IPR001849	Pleckstrin homology domain	PFAM	PF00169	PH	coord: 24..124 e-value: 5.1E-6 score: 26.8
IPR001849	Pleckstrin homology domain	PROSITE	PS50003	PH_DOMAIN	coord: 20..125 score: 9.17
IPR001895	Ras guanine-nucleotide exchange factors catalytic domain	SMART	SM00147	RasGEF_3	coord: 1114..1351 e-value: 3.9E-74 score: 262.3
IPR001895	Ras guanine-nucleotide exchange factors catalytic domain	PFAM	PF00617	RasGEF	coord: 1122..1299 e-value: 4.2E-49 score: 167.0
IPR001895	Ras guanine-nucleotide exchange factors catalytic domain	GENE3D	1.10.840.10		coord: 1106..1361 e-value: 3.1E-75 score: 252.6
IPR001895	Ras guanine-nucleotide exchange factors catalytic domain	PROSITE	PS50009	RASGEF_CAT	coord: 1118..1350 score: 60.838
IPR001895	Ras guanine-nucleotide exchange factors catalytic domain	CDD	cd00155	RasGEF	coord: 1114..1346 e-value: 1.09928E-64 score: 219.817
IPR011993	PH domain-like	GENE3D	2.30.29.30		coord: 442..603 e-value: 2.5E-18 score: 65.5
IPR011993	PH domain-like	GENE3D	2.30.29.30		coord: 4..137 e-value: 1.8E-9 score: 36.6
IPR011993	PH domain-like	SUPERFAMILY	50729	PH domain-like	coord: 21..125
IPR011993	PH domain-like	SUPERFAMILY	50729	PH domain-like	coord: 474..597
IPR000651	Ras-like guanine nucleotide exchange factor, N-terminal	PFAM	PF00618	RasGEF_N	coord: 631..698 e-value: 8.0E-11 score: 42.0
IPR000651	Ras-like guanine nucleotide exchange factor, N-terminal	PROSITE	PS50212	RASGEF_NTER	coord: 627..740 score: 8.885
IPR019804	Ras guanine-nucleotide exchange factor, conserved site	PROSITE	PS00720	RASGEF	coord: 1267..1297
IPR000048	IQ motif, EF-hand binding site	PROSITE	PS50096	IQ	coord: 201..225 score: 7.254
IPR023578	Ras guanine nucleotide exchange factor domain	SUPERFAMILY	48366	Ras GEF	coord: 625..681 coord: 998..1353

Blast

[Close]

BLAST of TCONS_00059321-protein vs. Swiss-Prot (Human)
Match: RGRF2 (Ras-specific guanine nucleotide-releasing factor 2 OS=Homo sapiens GN=RASGRF2 PE=1 SV=2)

HSP 1 Score: 550.051 bits (1416), Expect = 1.675e-173
Identity = 301/671 (44.86%), Postives = 428/671 (63.79%), Query Frame = 0

Query:   25 GCLKRLTRE-RKWIDRYCLLYQNFLIEFEDQCCLKATCLIPLEHYQAKRMEI------------NNIDDIYKQNVFYLCDISQKMLMLKQNEVYRANDETSCRDWVDAINQSSYAVLKSMKEELEYRNVHLLSVIESERETKWKLEEFAQEQRNQLESLRKEIPAMISKKVDEALQQNEPSTKESD-DLIKIKKIQSFFRGLICRRRWHSIVQDYIRSPHAESMRKRNCVVFQLVRSEEEYVECLSILVSAFYRPCKMAASSKNKPLSHDEVNSIFLNSETLMFLHQIFLKGLQTRMESWPKVVLGDLFDMLLPMLSIYQEYVRNHHYSLQTLSDCKQRSSFRKTLKSLENSTVAGNRTLDTFLTYPMHRIPKYIAAIQKLLALTQYDHVERVALEHSQSVLEELSSVMHDEVSETENIRKNLCIERMFTESCDFLLNTDEILIRQGVLLQLTMDYQNGKKLARKKSAETKTESVRHCFLFSQMFLVATRVSGGKLQLINKGKFM-LKNATLIEDIVDEDIDFINFPRASRHASLAFKLVVSDKDESAHKLILMAASPSDKAAWTSDISQCKENLRNPSEEETVSVQSRRSLLS--IRADTTLTTDAVDIKYSRALDSCRLPRIQYATVQRLLGRLLDVRFLSVEFLNTFLTTHSIFTTSSILMETIIEFY 678
            G L + T E  +W +++  LYQN L  FE +   +   +  LE    +R               + +D  Y   V +  +  QK L L      R  +E   ++W++AI+Q+SYA +   +E L  + +HL+ ++E+E+    +L    ++Q  ++E L+ EI A+   K  E ++  + + ++ D D+ KIKK+QSF RG +CRR+W +IVQDYI SPHAESMRKRN +VF +V +E EYV  L ILV+ F RP +MAASSK  P+SHD+V+SIFLNSET+MFLH+IF +GL+ R+ +WP ++L DLFD+LLPML+IYQE+VRNH YSLQ L++CKQ   F K LK  E +     R L+TFLTYPM +IP+YI  + +LLA T ++HVER +LE ++S LEELS VMHDEVS+TENIRKNL IERM  E CD LL+T +  IRQG L+Q+    +      R  S   K E  R CFLF++ FL+ TR SGGKL L+  G  + L + TLIE+    D D     +   H  L FK+VV   D +A  ++L+A S  +KAAW SDISQC +N+R       V  ++ +  +   I++D  L  D  DI +S+ L+SC++P+I+YA+V+RLL RL D+RFLS++FLNTFL T+ IFTT+++++  + + Y
Sbjct:   27 GFLSKKTAEASRWHEKWFALYQNVLFYFEGEQSCRPAGMYLLEGCSCERTPAPPRAGAGQGGVRDALDKQYYFTVLFGHE-GQKPLEL------RCEEEQDGKEWMEAIHQASYADILIEREVLMQKYIHLVQIVETEKIAANQLRHQLEDQDTEIERLKSEIIAL--NKTKERMRPYQSNQEDEDPDIKKIKKVQSFMRGWLCRRKWKTIVQDYICSPHAESMRKRNQIVFTMVEAESEYVHQLYILVNGFLRPLRMAASSKKPPISHDDVSSIFLNSETIMFLHEIFHQGLKARIANWPTLILADLFDILLPMLNIYQEFVRNHQYSLQVLANCKQNRDFDKLLKQYEANPACEGRMLETFLTYPMFQIPRYIITLHELLAHTPHEHVERKSLEFAKSKLEELSRVMHDEVSDTENIRKNLAIERMIVEGCDILLDTSQTFIRQGSLIQVPSVERGKLSKVRLGSLSLKKEGERQCFLFTKHFLICTRSSGGKLHLLKTGGVLSLIDCTLIEEPDASDDDSKGSGQVFGH--LDFKIVVEPPDAAAFTVVLLAPSRQEKAAWMSDISQCVDNIRCNGLMTIVFEENSKVTVPHMIKSDARLHKDDTDICFSKTLNSCKVPQIRYASVERLLERLTDLRFLSIDFLNTFLHTYRIFTTAAVVLGKLSDIY 686

HSP 2 Score: 300.056 bits (767), Expect = 1.025e-83
Identity = 149/319 (46.71%), Postives = 212/319 (66.46%), Query Frame = 0

Query: 1031 VTKRVLKILKHWVTKQPETIQRNKELKNKLENFLLKLIQMDDTAPIERKLANSILKSLVAGEQS-FKKNLLNVEILPSVEASSTFDQTSTLVIAEQMTLLDHILLKEIPSKEFLGATWMKDGKQKRAKNIMDAINQFNVTSRLVSTEILSRPTPALRASVIEKWTVVADMCRCLHNFNSVLAIITSFTSSAIFRLKKTWEKVSKQTQILIEKLKTIVSADGRFRNMREALKCCDPPSVPYLGFYLTDLASIEEQTSVIRESSLVNFAKMRMITNVIQEIRFYQSSSYMIEKNEKIMAYLMCVKHVKDEDRIYKLSLDLE 1348
             T RVL +L+HWV+K  +  + N ELK  + N L ++++  D  P ERK A +IL++L   +Q      L ++  +     +  F+  S + +AEQ+TLLDH++ + IP +EFLG  WMK  K +R   IM     FN  S LV+++I++    + RA+ IEKW  VAD+CRCLHN+N VL I ++   SAI+RLKKTW KVSKQT+ L++KL+  VS++GRF+N+RE LK C+PP+VPYLG YLTDLA IEE T    E  LVNF+KMRMI+++I+EIR +Q +SY I+   K+  YL+    + DED +Y+LSL +E
Sbjct:  914 ATNRVLNVLRHWVSKHAQDFELNNELKMNVLNLLEEVLRDPDLLPQERKAAANILRALSQDDQDDIHLKLEDIIQMTDCMKAECFESLSAMELAEQITLLDHVIFRSIPYEEFLGQGWMKLDKNERTPYIMKTSQHFNDMSNLVASQIMNYADVSSRANAIEKWVAVADICRCLHNYNGVLEITSALNRSAIYRLKKTWAKVSKQTKALMDKLQKTVSSEGRFKNLRETLKNCNPPAVPYLGMYLTDLAFIEEGTPNFTEEGLVNFSKMRMISHIIREIRQFQQTSYRIDHQPKVAQYLLDKDLIIDEDTLYELSLKIE 1232

The following BLAST results are available for this feature:

BLAST of TCONS_00059321-protein vs. Swiss-Prot (Human)

BLAST of TCONS_00059321-protein vs. Swiss-Prot (Human)
Analysis Date: 2018-01-31 (Blastp Clytia hemisphaerica v1.0 proteins vs SwissProt (Homo sapiens))
Total hits: 1


Match Name	E-value	Identity	Description
RGRF2	1.675e-173	44.86	Ras-specific guanine nucleotide-releasing factor 2...	[more]

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TCONS_00059321-protein (polypeptide) - C. hemisphaerica