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Sequence
The following sequences are available for this feature:
polypeptide sequence >TCONS_00062404-protein ID=TCONS_00062404-protein|Name=TCONS_00062404-protein|organism=Clytia hemisphaerica|type=polypeptide|length=1559bp
MTSPRLMKRKISLPMLRTPSRTRKTSSYGNRLDIDHLNEQSHMAFLRKVS
TNPHEIMYPINTVLPTGVKQVIVVPGTSKLREVLEELGDLLPDELETYVL
EDKQSRIINLNSPSVDFVGKELKVIKTSEQKTEDQIENTGRQQIVRDLCS
SEKQFHDRIRLAEVVYKIPLRSWGLNEAEVCLLFDGTTQVELTSNQLINK
LEEITVCWDNDDSLISDAFNDTFWSTHENYFNFFELAKLTLKSKRSDTSF
TSFLNMQRGVTGKPTLEALILAPLQRVPQYESFMTELISATPADHKDRKG
IEQTAARLRMLSEKRSENLLKEEQEFKIIQVQEKFPHDKLDLDLSWQEYE
RFKCRRYHHQSPGLRNKRSNPPDLGEDKEKKTPSSAEEQELHISPSPSTH
LTTKRLYIQEGPVKLSTATSTNERYLFLFNDLLIVAKPKSTSTFKLKERI
RVSELWLSNCIDEVTETTITHEKAFVIGWPTTNYVASFNLIEEKDLWYNA
LQKSINERKENEEPKEITIKVINKTQDDNTQPQQTCQVTVSCKDEAKTVL
KSSLEQFQQGNEDPSEYQLMILAKDGSTFPLIGHELPYAIRMNHIRALHE
YTHDENDNHYEQSGVLDDDGKLQFIVKKAKKGNTRNNLDIANNKKKWKIK
KSPIINWAMNKTTVKPAFNPQDSLPIGKLFRNPLIQLSNDENVIPKPILD
MLVQLFRRGPATSGIFRKPASARAAKQIRSLLDEGKDVDFEETSSIVIAT
VLKEFFRTLPESLIISDQYDNLLAAKSITDSDAKLETIKTILRQFPKCHY
ETLMRFLCILHHINRFSNRNKMTAYNLAICVSPSIMFLPANTKMVTEQAA
GGSDIVCFMIENYIKIFSEENEYCLGEESEIQLDDDRADDSDYGADETIY
KYDEEGDEREDSEKETEPITPDFLLSPVDGESVFSQSDSSLNTNDSDELK
MKLNIPSIALSAGSKSSPNSPMLTRRKKIEKSLSTDNKLNSDWSDQEGYD
SENFQRRLLRQPRPKRMLSSTTTSAELIEHKRQFTDSTASITSGEGVSPS
NSFNSLPSSATLVPQRHVMQQPVIHHFATDYRPTPNVIFHAVDRRRQPAA
PSYEEHIQRTQSKQRVVKTPTSKRQPVVAHTTVVQHQSSPVAQPKRDRPH
DLSLNTSKSSMSESNSQHSISSTSSNEERRSATLSRKPRVNKNEKPIVSP
KHTTKLSLEEKFFPKETSKSPGEPIKPRKKMTREENTTLEEFMNNFIESA
HVTPVENENRNIEDELQQELNKDNTIEDTFNSIMNSLQHNVQLNGNVTDR
KSSERRNSGKKRTPPPTAPKPRTSSSSSSDTNTASTTREVIGHEEIQSLN
NLLSSLENTATPTDEEGGGVFVEPSDTPRPSQSPFTLNLKTDLKKSPSNA
TNDEQNKAPSSLALEKKLLTKAPQKIDQLRLNSNERREEQGLNSRPMTAR
EMRRTNRRLKSEIRNAFNEGKFNTNSNERAESVRHKTLNINNFFNGHLTP
DSQMTQQNKENLIAEMLSRQCFPDSIETNNNTLDDYESEEKVESDTAFAK
IMSQAESYV Run BLAST on NCBI
Gene-mRNA-Prot
This polypeptide comes from the following gene feature:
This polypeptide derives from the following transcript feature(s):
Annotated Terms
The following terms have been associated with this polypeptide:
Vocabulary: Biological Process
| Term | Definition |
|---|
| GO:0035023 | regulation of Rho protein signal transduction |
| GO:0007165 | signal transduction |
Vocabulary: Molecular Function
| Term | Definition |
|---|
| GO:0005089 | Rho guanyl-nucleotide exchange factor activity |
GO Annotation
GO Assignments
This polypeptide is annotated with the following GO terms.
| Category |
Term Accession |
Term Name |
| biological_process |
GO:0035023 |
regulation of Rho protein signal transduction |
| biological_process |
GO:0007165 |
signal transduction |
| molecular_function |
GO:0005089 |
Rho guanyl-nucleotide exchange factor activity |
InterPro
Analysis Name: InterPro Annotations of C. hemisphaerica v1.0
Date Performed: 2017-06-01
| IPR Term | IPR Description | Source | Source Term | Source Description | Alignment |
|---|
| None | No IPR available | COILS | Coil | Coil | coord: 1449..1469 |
| None | No IPR available | GENE3D | 1.10.555.10 | | coord: 666..870
e-value: 6.8E-47
score: 159.1 |
| None | No IPR available | GENE3D | 3.10.20.90 | | coord: 516..635
e-value: 2.9E-8
score: 33.6 |
| None | No IPR available | GENE3D | 1.20.900.10 | | coord: 138..345
e-value: 4.8E-25
score: 87.8 |
| None | No IPR available | MOBIDB_LITE | mobidb-lite | disorder_prediction | coord: 1010..1058 |
| None | No IPR available | MOBIDB_LITE | mobidb-lite | disorder_prediction | coord: 980..999 |
| None | No IPR available | MOBIDB_LITE | mobidb-lite | disorder_prediction | coord: 1290..1343 |
| None | No IPR available | MOBIDB_LITE | mobidb-lite | disorder_prediction | coord: 360..398 |
| None | No IPR available | MOBIDB_LITE | mobidb-lite | disorder_prediction | coord: 901..923 |
| None | No IPR available | MOBIDB_LITE | mobidb-lite | disorder_prediction | coord: 1096..1232 |
| None | No IPR available | MOBIDB_LITE | mobidb-lite | disorder_prediction | coord: 1358..1410 |
| None | No IPR available | CDD | cd13319 | PH_RARhoGAP | coord: 405..501
e-value: 5.82214E-47
score: 164.334 |
| IPR000219 | Dbl homology (DH) domain | SMART | SM00325 | RhoGEF_3 | coord: 144..317
e-value: 0.0041
score: 10.6 |
| IPR000219 | Dbl homology (DH) domain | PFAM | PF00621 | RhoGEF | coord: 144..308
e-value: 1.5E-15
score: 57.8 |
| IPR000219 | Dbl homology (DH) domain | PROSITE | PS50010 | DH_2 | coord: 140..318
score: 14.093 |
| IPR000219 | Dbl homology (DH) domain | SUPERFAMILY | 48065 | DBL homology domain (DH-domain) | coord: 139..312 |
| IPR001849 | Pleckstrin homology domain | SMART | SM00233 | PH_update | coord: 407..508
e-value: 4.5E-5
score: 32.9 |
| IPR001849 | Pleckstrin homology domain | PROSITE | PS50003 | PH_DOMAIN | coord: 406..506
score: 7.967 |
| IPR000198 | Rho GTPase-activating protein domain | SMART | SM00324 | RhoGAP_3 | coord: 692..864
e-value: 3.5E-42
score: 156.1 |
| IPR000198 | Rho GTPase-activating protein domain | PFAM | PF00620 | RhoGAP | coord: 695..839
e-value: 4.5E-35
score: 120.6 |
| IPR000198 | Rho GTPase-activating protein domain | PROSITE | PS50238 | RHOGAP | coord: 685..867
score: 32.263 |
| IPR000159 | Ras-associating (RA) domain | PFAM | PF00788 | RA | coord: 520..596
e-value: 5.2E-7
score: 30.1 |
| IPR000159 | Ras-associating (RA) domain | PROSITE | PS50200 | RA | coord: 515..631
score: 9.47 |
| IPR011993 | PH domain-like | GENE3D | 2.30.29.30 | | coord: 401..515
e-value: 2.1E-19
score: 69.1 |
| IPR011993 | PH domain-like | SUPERFAMILY | 50729 | PH domain-like | coord: 398..514 |
| IPR029071 | Ubiquitin-related domain | SUPERFAMILY | 54236 | Ubiquitin-like | coord: 527..597 |
| IPR008936 | Rho GTPase activation protein | SUPERFAMILY | 48350 | GTPase activation domain, GAP | coord: 689..870 |
Blast
BLAST of TCONS_00062404-protein vs. Swiss-Prot (Human)
Match: RHG20 (Rho GTPase-activating protein 20 OS=Homo sapiens GN=ARHGAP20 PE=1 SV=2) HSP 1 Score: 290.812 bits (743), Expect = 1.563e-80 Identity = 178/525 (33.90%), Postives = 300/525 (57.14%), Query Frame = 0
Query: 364 LRNKRSNPPDLGEDKE-KKTPSSAEEQELHISPSP--STHLTTKRLYIQEGPVKLSTATSTNERYLFLFNDLLIVAKPKSTSTFKLKERIRVSELWLSNCIDEVTETTITHEKAFVIGWPTTNYVASFNLIEEKDLWYNALQKSINERKENEEPKEITIKVINKTQDDNTQPQQTCQVTVSCKDEAKTVLKSSLEQFQ-QGNEDPSEYQLMI-LAKDGSTFPLIGHELPYAIRMNHIRALHEYTHDENDN----HYEQSGVLDD---DGKLQFIVKKAKKGNTRNNLDIANNKKKWKIKKSPIINWAMNKTTVKPAFN----PQDSLPIGKLFRNPLIQLSNDENVIPKPILDMLVQLFRRGPATSGIFRKPASARAAKQIRSLLDEGKDVDFEETSSIVIATVLKEFFRTLPESLIISDQYDNLLAAKSITDSDAKLETIKTILRQFPKCHYETLMRFLCILHHINRFSNRNKMTAYNLAICVSPSIMFLPANT--KMVTEQAAGGSDIVCFMIENYIKIFSEE 870
L +R + P L DK +K P++ + + S+ + + R + +G +L ER+LFLFNDL +VAK K + FK+K +I+++++W ++C+DEV E K+FV+GWPT N+VA+F+ E+KD W + LQ+ IN KE + PK I +K+ K D + +TV D A V+ SL G+E +YQL + K+ + +PLIGHE PY I+M+H+R T D+ + ++ +++ + + QFI+K ++ + D + K +K ++S IINWA + + N P +P G+LF L + ++N +PKP+LDML L ++GP T GIFR+ A+ ++ ++++ L+ G +V + S VIA+VLK+F R +P S+ SD YD+ ++ + + K+ T++ +L Q P+ + L +LH+I + S+ N+MTA+NLA+CV+PSI++ PA++ ++ E S ++ F+IEN ++IF EE
Sbjct: 40 LAERRRSAPSLILDKALQKRPTTRDSPSASVDTCTFLSSLVCSNRTLLIDGRAELKRGLQRQERHLFLFNDLFVVAKIKYNNNFKIKNKIKLTDMWTASCVDEVGEGNTNAMKSFVLGWPTVNFVATFSSPEQKDKWLSLLQRYINLEKEKDYPKSIPLKIFAK---DIGNCAYSKTITVMNSDTANEVINMSLPMLGITGSE--RDYQLWVNSGKEEAPYPLIGHEYPYGIKMSHLRDSALLTPGSKDSTTPFNLQEPFLMEQLPREMQCQFILKPSRLAAAQQLSD--SGHKTFKRRRS-IINWAFWRGSSTHLDNLPSSPTSPMP-GQLFGISLPNICENDN-LPKPVLDMLFFLNQKGPLTKGIFRQSANVKSCRELKEKLNSGVEVHLDCESIFVIASVLKDFLRNIPGSIFSSDLYDHWVSVMDQGNDEEKINTVQRLLDQLPRANVVLLRYLFGVLHNIEQHSSSNQMTAFNLAVCVAPSILWPPASSSPELENEFTKKVSLLIQFLIENCLRIFGEE 554
The following BLAST results are available for this feature:
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