TCONS_00049088-protein (polypeptide) - C. hemisphaerica

Overview
NameTCONS_00049088-protein
Unique NameTCONS_00049088-protein
Typepolypeptide
OrganismClytia hemisphaerica (Jellyfish)
Sequence length849

Sequence
The following sequences are available for this feature:

polypeptide sequence

>TCONS_00049088-protein ID=TCONS_00049088-protein|Name=TCONS_00049088-protein|organism=Clytia hemisphaerica|type=polypeptide|length=849bp
MTFYKQIVSFRTCGIFLLVSLATMLPFVYGDECNFGKISSEYRWRPCPSI
NRTTVEDCIQQNCCYNNTINSQFNCWKKQKSEAGIKNGTCLPYTGSVCAD
NFNQSMLTNTRRLFDRKYQVNVTDRIMIKLFEIFQKIRIDAKCKNLLESI
ACPFVMPECTSDDMFFAPCREDCEYLSANCNKGSQTAYALGQIDLILYNE
GYDFYHLNPSRIMACDLYQYSYNPGVQCMKLIHGIDRSKPPDDNKIIIIA
GAAGGAVFLVFILCLILCCYRRNERIKKEKLYQTEMEYVSNMTSIREHIR
SADSTINPLMELLASSKPGELIQYPVDCIEYVKELGEGQFGKVFQGRVHG
VVKGEESTDVAVKCLKEGSSDVAKASFNQEVALMSVLQHNNILRLLAVST
EEEPYCMIFEFMEKGDLNEFLRQWNSKEYLNDSQLIKICKHVAAGMEYLA
SKKFLHRDLATRNCLVGKDLMVKIADFGMSRNVYHSDYYRVGGEAMLPIR
WMPPESILYGKFTVASDVYSFGVVMWEIFSFALQPFYGYGNEEVIEFIKK
GVLLPKPEDCPEWIYNIMLNCWKTDVEERITFTKAYQMLKGQFHQDKAED
CTTDNYDRLPSEIRPATEGGNPQSDPSTNHEGYDRVTVSQQPPQRTHNDY
DKVWNEPEVKQSTDFNQTPGYINLPNLTKESSKRESSEDLPRSPSTDPGS
PNMGFDDDERNLLRPQSTSSLTKGSPSISLKSLTPKALKKNNKTKQQEFQ
SNEALLQHRRSLQGSRSIKDVMKTDKGGPRYVKSDDVKRISQNSDRQSQH
GEVHEDKPEYIGAFRPTSEFLPFHGYGESIQANDPDEAKLIKKIIEESN
Run BLAST on NCBI
Gene-mRNA-Prot
This polypeptide comes from the following gene feature:
Feature NameUnique NameSpeciesType
XLOC_031194XLOC_031194Clytia hemisphaericagene
This polypeptide derives from the following transcript feature(s):
Feature NameUnique NameSpeciesType
TCONS_00049088TCONS_00049088Clytia hemisphaericatranscript
Annotated Terms
The following terms have been associated with this polypeptide:
Vocabulary: INTERPRO
TermDefinition
IPR001245Ser-Thr/Tyr_kinase_cat_dom
IPR020635Tyr_kinase_cat_dom
IPR020067Frizzled_dom
IPR002011Tyr_kinase_rcpt_2_CS
IPR008266Tyr_kinase_AS
IPR017441Protein_kinase_ATP_BS
IPR000719Prot_kinase_dom
IPR011009Kinase-like_dom
Vocabulary: Molecular Function
TermDefinition
GO:0004672protein kinase activity
GO:0004713protein tyrosine kinase activity
GO:0005515protein binding
GO:0005524ATP binding
GO:0004714transmembrane receptor protein tyrosine kinase activity
Vocabulary: Biological Process
TermDefinition
GO:0006468protein phosphorylation
GO:0007169transmembrane receptor protein tyrosine kinase signaling pathway
Vocabulary: Cellular Component
TermDefinition
GO:0016020membrane
GO Annotation
GO Assignments
This polypeptide is annotated with the following GO terms.
Category Term Accession Term Name
biological_process GO:0006468 protein phosphorylation
biological_process GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
cellular_component GO:0016020 membrane
molecular_function GO:0005524 ATP binding
molecular_function GO:0005515 protein binding
molecular_function GO:0004672 protein kinase activity
molecular_function GO:0004713 protein tyrosine kinase activity
molecular_function GO:0004714 transmembrane receptor protein tyrosine kinase activity
InterPro
Analysis Name: InterPro Annotations of C. hemisphaerica v1.0
Date Performed: 2017-06-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR001245Serine-threonine/tyrosine-protein kinase, catalytic domainPRINTSPR00109TYRKINASEcoord: 409..422
score: 51.47
coord: 448..466
score: 62.83
coord: 560..582
score: 42.3
coord: 516..538
score: 49.96
coord: 497..507
score: 56.7
IPR001245Serine-threonine/tyrosine-protein kinase, catalytic domainPFAMPF07714Pkinase_Tyrcoord: 330..587
e-value: 7.2E-93
score: 310.5
IPR020635Tyrosine-protein kinase, catalytic domainSMARTSM00219tyrkin_6coord: 329..589
e-value: 7.9E-126
score: 434.0
NoneNo IPR availableGENE3D1.20.5.510coord: 235..273
e-value: 8.5E-8
score: 31.4
NoneNo IPR availableGENE3D3.30.200.20coord: 315..415
e-value: 3.2E-22
score: 78.1
NoneNo IPR availableGENE3D1.10.510.10coord: 416..776
e-value: 5.1E-49
score: 166.3
NoneNo IPR availableMOBIDB_LITEmobidb-litedisorder_predictioncoord: 601..810
NoneNo IPR availableCDDcd00192PTKccoord: 333..590
e-value: 4.78342E-125
score: 378.42
IPR020067Frizzled domainGENE3D1.10.2000.10coord: 81..234
e-value: 7.4E-12
score: 45.1
IPR020067Frizzled domainPFAMPF01392Fzcoord: 90..184
e-value: 8.7E-8
score: 32.7
IPR020067Frizzled domainPROSITEPS50038FZcoord: 85..231
score: 12.242
IPR020067Frizzled domainSUPERFAMILY63501Frizzled cysteine-rich domaincoord: 88..182
IPR002011Tyrosine-protein kinase, receptor class II, conserved sitePROSITEPS00239RECEPTOR_TYR_KIN_IIcoord: 482..490
IPR008266Tyrosine-protein kinase, active sitePROSITEPS00109PROTEIN_KINASE_TYRcoord: 454..466
IPR017441Protein kinase, ATP binding sitePROSITEPS00107PROTEIN_KINASE_ATPcoord: 335..363
IPR000719Protein kinase domainPROSITEPS50011PROTEIN_KINASE_DOMcoord: 329..589
score: 35.623
IPR011009Protein kinase-like domainSUPERFAMILY56112Protein kinase-like (PK-like)coord: 308..589

Blast
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BLAST of TCONS_00049088-protein vs. Swiss-Prot (Human)
Match: MUSK (Muscle, skeletal receptor tyrosine-protein kinase OS=Homo sapiens GN=MUSK PE=1 SV=1)

HSP 1 Score: 291.967 bits (746), Expect = 8.047e-86
Identity = 151/375 (40.27%), Postives = 227/375 (60.53%), Query Frame = 0 
Query:  241 PDDNKIIIIAGAAGGAVFLVFILCLILCCYRRNE--RIKKEKLYQTEMEYVSNMTSIREHIRSADSTINPLMELL--ASSKPGELIQYPVDCIEYVKELGEGQFGKVFQGRVHGVVKGEESTDVAVKCLKEGSSDVAKASFNQEVALMSVLQHNNILRLLAVSTEEEPYCMIFEFMEKGDLNEFLRQWNSKEY---------------------LNDSQLIKICKHVAAGMEYLASKKFLHRDLATRNCLVGKDLMVKIADFGMSRNVYHSDYYRVGGEAMLPIRWMPPESILYGKFTVASDVYSFGVVMWEIFSFALQPFYGYGNEEVIEFIKKGVLLPKPEDCPEWIYNIMLNCWKTDVEERITFTKAYQMLK 590
            P  +  +II+  +  A+F++  +  + CC RR +    K+E    T     S +   R H        NP+ + +    +     ++YP + IEYV+++GEG FG+VFQ R  G++  E  T VAVK LKE +S   +A F +E ALM+   + NI++LL V    +P C++FE+M  GDLNEFLR  +                         L+ ++ + I + VAAGM YL+ +KF+HRDLATRNCLVG++++VKIADFG+SRN+Y +DYY+      +PIRWMPPESI Y ++T  SDV+++GVV+WEIFS+ LQP+YG  +EEVI +++ G +L  PE+CP  +YN+M  CW     +R +FT  +++L+
Sbjct:  490 PTYSMTVIISIMSSFAIFVLLTITTLYCCRRRKQWKNKKRESAAVTLTTLPSELLLDRLHP-------NPMYQRMPLLLNPKLLSLEYPRNNIEYVRDIGEGAFGRVFQARAPGLLPYEPFTMVAVKMLKEEASADMQADFQREAALMAEFDNPNIVKLLGVCAVGKPMCLLFEYMAYGDLNEFLRSMSPHTVCSLSHSDLSMRAQVSSPGPPPLSCAEQLCIARQVAAGMAYLSERKFVHRDLATRNCLVGENMVVKIADFGLSRNIYSADYYKANENDAIPIRWMPPESIFYNRYTTESDVWAYGVVLWEIFSYGLQPYYGMAHEEVIYYVRDGNILSCPENCPVELYNLMRLCWSKLPADRPSFTSIHRILE 857
The following BLAST results are available for this feature:
BLAST of TCONS_00049088-protein vs. Swiss-Prot (Human)
Analysis Date: 2018-01-31 (Blastp Clytia hemisphaerica v1.0 proteins vs SwissProt (Homo sapiens))
Total hits: 1
Match NameE-valueIdentityDescription
MUSK8.047e-8640.27Muscle, skeletal receptor tyrosine-protein kinase ... [more]
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