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Sequence
The following sequences are available for this feature:
polypeptide sequence >TCONS_00064520-protein ID=TCONS_00064520-protein|Name=TCONS_00064520-protein|organism=Clytia hemisphaerica|type=polypeptide|length=376bp
MDMLCLYCVIMKDLVALETAIKDHVEHNDVKLINFHKMVQVSDILNKVTG
LRDTSPDVVPDKELSNIMRLSLKSRYSEDDLYELSAQREPRSTHKQSTSI
SPGLERPDFADWAAGITPETPDRATVEKYILNMVEAVFKTYDVDKNGSIN
KEEFDQLATNFPFIDNFAVLDVNCDGDISRQEMVNYFMNANSQEMTKEFL
HDFQEHAFYSPTYCVYCMGFLWGIGKSGYRCKVCQIVCHKDCKNHVVMEC
RPQRSFSMRDPKKSLKKRMNHDSSWQGSTDSVVNESLDSTTISRFSDSSV
DFSDALIIERLKERITRLEVEKIEMKKENSTLKTKLNTAEKQVESLQSQL
EQIRPLSVKFMLDQLERLSTCKETDL Run BLAST on NCBI
Gene-mRNA-Prot
This polypeptide comes from the following gene feature:
This polypeptide derives from the following transcript feature(s):
Annotated Terms
The following terms have been associated with this polypeptide:
Vocabulary: Molecular Function
| Term | Definition |
|---|
| GO:0005509 | calcium ion binding |
| GO:0005085 | guanyl-nucleotide exchange factor activity |
Vocabulary: Biological Process
| Term | Definition |
|---|
| GO:0035556 | intracellular signal transduction |
| GO:0007264 | small GTPase mediated signal transduction |
GO Annotation
GO Assignments
This polypeptide is annotated with the following GO terms.
| Category |
Term Accession |
Term Name |
| biological_process |
GO:0035556 |
intracellular signal transduction |
| biological_process |
GO:0007264 |
small GTPase mediated signal transduction |
| molecular_function |
GO:0005509 |
calcium ion binding |
| molecular_function |
GO:0005085 |
guanyl-nucleotide exchange factor activity |
InterPro
Analysis Name: InterPro Annotations of C. hemisphaerica v1.0
Date Performed: 2017-06-01
| IPR Term | IPR Description | Source | Source Term | Source Description | Alignment |
|---|
| None | No IPR available | COILS | Coil | Coil | coord: 308..349 |
| None | No IPR available | GENE3D | 1.10.238.10 | | coord: 175..198
e-value: 0.0069
score: 15.8 |
| None | No IPR available | GENE3D | 3.30.60.20 | | coord: 199..252
e-value: 3.9E-18
score: 64.6 |
| None | No IPR available | GENE3D | 1.10.238.10 | | coord: 127..174
e-value: 1.2E-8
score: 34.2 |
| None | No IPR available | GENE3D | 1.20.5.170 | | coord: 259..369
e-value: 1.0E-6
score: 28.2 |
| None | No IPR available | MOBIDB_LITE | mobidb-lite | disorder_prediction | coord: 84..106 |
| None | No IPR available | SUPERFAMILY | 57889 | Cysteine-rich domain | coord: 189..251 |
| IPR020454 | Diacylglycerol/phorbol-ester binding | PRINTS | PR00008 | DAGPEDOMAIN | coord: 214..223
score: 46.73
coord: 239..251
score: 34.81
coord: 198..212
score: 30.5
coord: 227..238
score: 37.46 |
| IPR002048 | EF-hand domain | SMART | SM00054 | efh_1 | coord: 133..161
e-value: 8.6E-4
score: 28.6
coord: 162..190
e-value: 12.0
score: 9.0 |
| IPR002048 | EF-hand domain | PFAM | PF13202 | EF-hand_5 | coord: 167..184
e-value: 0.0051
score: 16.2
coord: 135..157
e-value: 0.0013
score: 18.1 |
| IPR002048 | EF-hand domain | PROSITE | PS50222 | EF_HAND_2 | coord: 167..193
score: 8.265 |
| IPR002048 | EF-hand domain | PROSITE | PS50222 | EF_HAND_2 | coord: 129..164
score: 12.003 |
| IPR002219 | Protein kinase C-like, phorbol ester/diacylglycerol-binding domain | SMART | SM00109 | c1_12 | coord: 201..250
e-value: 5.7E-13
score: 59.1 |
| IPR002219 | Protein kinase C-like, phorbol ester/diacylglycerol-binding domain | PFAM | PF00130 | C1_1 | coord: 201..252
e-value: 3.9E-14
score: 52.2 |
| IPR002219 | Protein kinase C-like, phorbol ester/diacylglycerol-binding domain | PROSITE | PS00479 | ZF_DAG_PE_1 | coord: 201..250 |
| IPR002219 | Protein kinase C-like, phorbol ester/diacylglycerol-binding domain | PROSITE | PS50081 | ZF_DAG_PE_2 | coord: 200..250
score: 14.587 |
| IPR002219 | Protein kinase C-like, phorbol ester/diacylglycerol-binding domain | CDD | cd00029 | C1 | coord: 201..250
e-value: 5.25724E-17
score: 73.2951 |
| IPR001895 | Ras guanine-nucleotide exchange factors catalytic domain | GENE3D | 1.10.840.10 | | coord: 5..113
e-value: 5.0E-14
score: 51.7 |
| IPR018247 | EF-Hand 1, calcium-binding site | PROSITE | PS00018 | EF_HAND_1 | coord: 142..154 |
| IPR018247 | EF-Hand 1, calcium-binding site | PROSITE | PS00018 | EF_HAND_1 | coord: 171..183 |
| IPR011992 | EF-hand domain pair | SUPERFAMILY | 47473 | EF-hand | coord: 104..203 |
| IPR023578 | Ras guanine nucleotide exchange factor domain | SUPERFAMILY | 48366 | Ras GEF | coord: 9..96 |
Blast
BLAST of TCONS_00064520-protein vs. Swiss-Prot (Human)
Match: GRP3 (Ras guanyl-releasing protein 3 OS=Homo sapiens GN=RASGRP3 PE=1 SV=1) HSP 1 Score: 208.764 bits (530), Expect = 2.656e-61 Identity = 104/246 (42.28%), Postives = 158/246 (64.23%), Query Frame = 0
Query: 9 VIMKDLVALETAIKDHVEHNDVKLINFHKMVQVSDILNKVTGLRDTSPDVVPDKELSNIMRLSLKSRYSEDDLYELSAQREPRSTHKQSTSISPGLERPDFADWAAGITPETPDRATVEKYILNMVEAVFKTYDVDKNGSINKEEFDQLATNFPFIDNFAVLDVNCDGDISRQEMVNYFMNANSQ---EMTKEFLHDFQEHAFYSPTYCVYCMGFLWGIGKSGYRCKVCQIVCHKDCKNHVVMECR 251
V +KDL+A+ D E N V ++ KM Q+S L+++ L++ S + P+ +L N++ LSL ++EDD+Y+LS EPR++ Q TS + + +WA G+ P+ PD + K+I +VE+VF+ YD D +G I++E+F+ +A NFPF+D+F VLD + DG IS+ EM+ YF+ A SQ +M F+H+FQE + PT+C +C GFLWGI K GY+CK C CHK CK+ +V+ CR
Sbjct: 304 VHLKDLIAVHVIFPDWTEENKVNIV---KMHQLSVTLSELVSLQNASHHLEPNMDLINLLTLSLDLYHTEDDIYKLSLVLEPRNSKSQPTSPTTPNKPVVPLEWALGVMPK-PDPTVINKHIRKLVESVFRNYDHDHDGYISQEDFESIAANFPFLDSFCVLDKDQDGLISKDEMMAYFLRAKSQLHCKMGPGFIHNFQEMTYLKPTFCEHCAGFLWGIIKQGYKCKDCGANCHKQCKDLLVLACR 545
The following BLAST results are available for this feature:
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