TCONS_00067589-protein (polypeptide) - C. hemisphaerica

BLAST of TCONS_00067589-protein vs. Swiss-Prot (Human)
Match: MDR1 (Multidrug resistance protein 1 OS=Homo sapiens GN=ABCB1 PE=1 SV=3)

HSP 1 Score: 1169.07 bits (3023), Expect = 0.000e+0
Identity = 605/1259 (48.05%), Postives = 834/1259 (66.24%), Query Frame = 0

Query:   71 PVVSVRQLFRYASTNDWIFMFLASISACINGMLQPISFILFGELIDDFVE-----------------QDAGKTIDLNKEMEKFGIYYVYIGLGAIVFGYFQNMLWLRASINQAFKIRTLAFESILRQDIGFFDTNDAGELTSRLADGVTKIQSGIGDKIGSLQHAIAMLIGGTIIGFIYGWKLTLVIIAMSPLLFIGAFATGKVIGTITSQEQTSYAKAGSIAEEVLSSIRTVVAFGSEKKETDRYCVHLKDAERAGIRKGLSTGFAFALFNLTTFGCMALGFWYGGTLISESEMTAGNLLIVFFSILMGASQFGQVSPNMEVFSSARGAAYPIYQLIERQPEIDSLSESGEMI-KIEGDIRFQDCHFAYPSRPNVQVLRGFNLRIKPGTTCALVGESGCGKSTTVKLIQRFYDVARGDVQIDSVGIKSINVKHLRRHIGVVSQEPVLFDASIKKNILMGHPEASEEMVIQAAKNANAHGFITELPQGYDTNVGEGGAQLSGGQKQRIAIARALVRDPKILLLDEATSALDTGSEAIVQGALDKASFGRTTIIIAHRLSTVKNADQIAVVSNGQVCELGSHKELIDKRGEYFKMVTLQNLAAQKEDSNEPSSVLGDFTDIDEELLKESAFHEKSKHDTLQ----NVESTTSAKRQTSNKLQPQSSQTRQ-DEKETPDESVKTPPLGRILKLNANEWPYILLGVFFSAIAGAMPVVAAIIMAEILQSFAEVDANEMKKK-MEFWSIMFMVLGLVIAIAFFIAQYLFSKAGEALTTRLREMAFTALLRQEIGFFDLPQHNTGALSARLSADAAAVQGATSTRLNTLTQVVVSGLSSLIVAFAYSWQLTLLVLAFVPFIAMFGGIQTSLNTSFAGNAQETLSQAGAISTEAIMQIRTVASLGKEDYFIEKYKSLLSGPTQGSLKSAHIYGLAYGFSTGVMMFSDGACFRLGGYLAEKDGLPLSAIMKVIIGIQFGAMTAGQTASYAPDYVKAKTAAGRILALFDREPVIDSYSSEG-MKNVIKGDITFKDVEFAYPTRENVEVLQKLNLTIPCGRTVAFVGASGCGKSTSVSLLERFYDVTGGKVLIDDILIKDYNIRSLRSQIGIVQQEPVLFDRSIRDNILYGIEDTSQITKETIETACTNSNIHHVIMGLPNGYETHVGDKGTLISGGQKQRIAIARALIRNPKILLLDEATSALDSESEKVVQEALDRAMEGRTSIVIAHRLSTIQNADVIAVIQNGKIMEIGSHFELMALKGAYYSL 1304
            P VSV  +FRY++  D ++M + +++A I+G   P+  ++FGE+ D F                    D G  ++L ++M ++  YY  IG G +V  Y Q   W  A+  Q  KIR   F +I+RQ+IG+FD +D GEL +RL D V+KI  GIGDKIG    ++A    G I+GF  GWKLTLVI+A+SP+L + A    K++ + T +E  +YAKAG++AEEVL++IRTV+AFG +KKE +RY  +L++A+R GI+K ++   +     L  +   AL FWYG TL+   E + G +L VFFS+L+GA   GQ SP++E F++ARGAAY I+++I+ +P IDS S+SG     I+G++ F++ HF+YPSR  V++L+G NL+++ G T ALVG SGCGKSTTV+L+QR YD   G V +D   I++INV+ LR  IGVVSQEPVLF  +I +NI  G    + + + +A K ANA+ FI +LP  +DT VGE GAQLSGGQKQRIAIARALVR+PKILLLDEATSALDT SEA+VQ ALDKA  GRTTI+IAHRLSTV+NAD IA   +G + E G+H EL+ ++G YFK+VT+Q    + E                   L+ +A   KS+ D L+    +  S+   KR T   ++   +Q R+   KE  DES+      RI+KLN  EWPY ++GVF + I G +    AII ++I+  F  +D  E K++    +S++F+ LG++  I FF+  + F KAGE LT RLR M F ++LRQ++ +FD P++ TGAL+ RL+ DAA V+GA  +RL  +TQ + +  + +I++F Y WQLTLL+LA VP IA+ G ++  + +  A   ++ L  +G I+TEAI   RTV SL +E  F   Y   L  P + SL+ AHI+G+ + F+  +M FS   CFR G YL     +    ++ V   + FGAM  GQ +S+APDY KAK +A  I+ + ++ P+IDSYS+EG M N ++G++TF +V F YPTR ++ VLQ L+L +  G+T+A VG+SGCGKST V LLERFYD   GKVL+D   IK  N++ LR+ +GIV QEP+LFD SI +NI YG +++  +++E I  A   +NIH  I  LPN Y T VGDKGT +SGGQKQRIAIARAL+R P ILLLDEATSALD+ESEKVVQEALD+A EGRT IVIAHRLSTIQNAD+I V QNG++ E G+H +L+A KG Y+S+
Sbjct:   32 PTVSVFSMFRYSNWLDKLYMVVGTLAAIIHGAGLPLMMLVFGEMTDIFANAGNLEDLMSNITNRSDINDTGFFMNLEEDMTRYAYYYSGIGAGVLVAAYIQVSFWCLAAGRQIHKIRKQFFHAIMRQEIGWFDVHDVGELNTRLTDDVSKINEGIGDKIGMFFQSMATFFTGFIVGFTRGWKLTLVILAISPVLGLSAAVWAKILSSFTDKELLAYAKAGAVAEEVLAAIRTVIAFGGQKKELERYNKNLEEAKRIGIKKAITANISIGAAFLLIYASYALAFWYGTTLVLSGEYSIGQVLTVFFSVLIGAFSVGQASPSIEAFANARGAAYEIFKIIDNKPSIDSYSKSGHKPDNIKGNLEFRNVHFSYPSRKEVKILKGLNLKVQSGQTVALVGNSGCGKSTTVQLMQRLYDPTEGMVSVDGQDIRTINVRFLREIIGVVSQEPVLFATTIAENIRYGRENVTMDEIEKAVKEANAYDFIMKLPHKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQVALDKARKGRTTIVIAHRLSTVRNADVIAGFDDGVIVEKGNHDELMKEKGIYFKLVTMQTAGNEVE-------------------LENAADESKSEIDALEMSSNDSRSSLIRKRSTRRSVRGSQAQDRKLSTKEALDESIPPVSFWRIMKLNLTEWPYFVVGVFCAIINGGLQPAFAIIFSKIIGVFTRIDDPETKRQNSNLFSLLFLALGIISFITFFLQGFTFGKAGEILTKRLRYMVFRSMLRQDVSWFDDPKNTTGALTTRLANDAAQVKGAIGSRLAVITQNIANLGTGIIISFIYGWQLTLLLLAIVPIIAIAGVVEMKMLSGQALKDKKELEGSGKIATEAIENFRTVVSLTQEQKFEHMYAQSLQVPYRNSLRKAHIFGITFSFTQAMMYFSYAGCFRFGAYLVAHKLMSFEDVLLVFSAVVFGAMAVGQVSSFAPDYAKAKISAAHIIMIIEKTPLIDSYSTEGLMPNTLEGNVTFGEVVFNYPTRPDIPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGKVLLDGKEIKRLNVQWLRAHLGIVSQEPILFDCSIAENIAYG-DNSRVVSQEEIVRAAKEANIHAFIESLPNKYSTKVGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYFSM 1270          

HSP 2 Score: 443.736 bits (1140), Expect = 4.163e-134
Identity = 247/589 (41.94%), Postives = 359/589 (60.95%), Query Frame = 0

Query:   71 PVVSVRQLFRYASTNDWIFMFLASISACINGMLQPISFILFGELIDDFVEQDAGKTIDLNKEMEKFGIYYVYIGLGAIVFGYFQNMLWLRASINQAFKIRTLAFESILRQDIGFFD--TNDAGELTSRLADGVTKIQSGIGDKIGSLQHAIAMLIGGTIIGFIYGWKLTLVIIAMSPLLFIGAFATGKVIGTITSQEQTSYAKAGSIAEEVLSSIRTVVAFGSEKKETDRYCVHLKDAERAGIRK----GLSTGFAFALFNLTTFGCMALGFWYGGTLISESEMTAGNLLIVFFSILMGASQFGQVSPNMEVFSSARGAAYPIYQLIERQPEIDSLSESGEMIK-IEGDIRFQDCHFAYPSRPNVQVLRGFNLRIKPGTTCALVGESGCGKSTTVKLIQRFYDVARGDVQIDSVGIKSINVKHLRRHIGVVSQEPVLFDASIKKNILMGHPE--ASEEMVIQAAKNANAHGFITELPQGYDTNVGEGGAQLSGGQKQRIAIARALVRDPKILLLDEATSALDTGSEAIVQGALDKASFGRTTIIIAHRLSTVKNADQIAVVSNGQVCELGSHKELIDKRGEYFKMVTLQ 650
            P VS  ++ +   T +W +  +    A ING LQP   I+F ++I  F   D  +T   N  +  F + ++ +G+ + +  + Q   + +A      ++R + F S+LRQD+ +FD   N  G LT+RLA+   +++  IG ++  +   IA L  G II FIYGW+LTL+++A+ P++ I      K++     +++     +G IA E + + RTVV+   E+K    Y   L+   R  +RK    G++  F  A+   +  GC    F +G  L++   M+  ++L+VF +++ GA   GQVS     ++ A+ +A  I  +IE+ P IDS S  G M   +EG++ F +  F YP+RP++ VL+G +L +K G T ALVG SGCGKST V+L++RFYD   G V +D   IK +NV+ LR H+G+VSQEP+LFD SI +NI  G      S+E +++AAK AN H FI  LP  Y T VG+ G QLSGGQKQRIAIARALVR P ILLLDEATSALDT SE +VQ ALDKA  GRT I+IAHRLST++NAD I V  NG+V E G+H++L+ ++G YF MV++Q
Sbjct:  693 PPVSFWRIMKLNLT-EWPYFVVGVFCAIINGGLQPAFAIIFSKIIGVFTRIDDPETKRQNSNL--FSLLFLALGIISFITFFLQGFTFGKAGEILTKRLRYMVFRSMLRQDVSWFDDPKNTTGALTTRLANDAAQVKGAIGSRLAVITQNIANLGTGIIISFIYGWQLTLLLLAIVPIIAIAGVVEMKMLSGQALKDKKELEGSGKIATEAIENFRTVVSLTQEQKFEHMYAQSLQVPYRNSLRKAHIFGITFSFTQAMMYFSYAGC----FRFGAYLVAHKLMSFEDVLLVFSAVVFGAMAVGQVSSFAPDYAKAKISAAHIIMIIEKTPLIDSYSTEGLMPNTLEGNVTFGEVVFNYPTRPDIPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGKVLLDGKEIKRLNVQWLRAHLGIVSQEPILFDCSIAENIAYGDNSRVVSQEEIVRAAKEANIHAFIESLPNKYSTKVGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYFSMVSVQ 1274